Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Citrate-sodium symport Klebsiella pneumoniae P31602 MTNMSQPPAT EKKGVSDLLG FKIFGMPLPL YAFALITLLL SHFYNALPTD IVGGFAIMFI IGAIFGEIGK RLPIFNKYIG GAPVMIFLVA AYFVYAGIFT QKEIDAISNV MDKSNFLNLF IAVLITGAIL SVNRRLLLKS LLGYIPTILM GIVGASIFGI AIGLVFGIPV DRIMMLYVLP IMGGGNGAGA VPLSEIYHSV TGRSREEYYS TAIAILTIAN IFAIVFAAVL DIIGKKHTWL SGEGELVRKA SFKVEEDEKT GQITHRETAV GLVLSTTCFL LAYVVAKKIL PSIGGVAIHY FAWMVLIVAA LNASGLCSPE IKAGAKRLSD FFSKQLLWVL MVGVGVCYTD LQEIINAITF ANVVIAAIIV IGAVLGAAIG GWLMGFFPIE SAITAGLCMA NRGGSGDLEV LSACNRMNLI SYAQISSRLG GGIVLVIASI VFGMMI Bacterial inner membrane;Cytoplasm;Periplasmic space 71 Fusion BAD yes 300 Fusion PhoA 770 6339478 Fusion PhoA 30 6339478 Fusion PhoA 126 6339478 Fusion PhoA 12 6339478 Fusion PhoA 650 6339478 Fusion PhoA 300 6339478 Fusion PhoA 15 6339478 Fusion PhoA 0 6339478 Fusion PhoA 295 6339478 Fusion PhoA 162 6339478 Fusion PhoA 73 6339478 Fusion PhoA 583 6339478 Fusion PhoA 450 6339478 Fusion PhoA 176 6339478 Fusion PhoA 211 6339478 Fusion PhoA 6 6339478 Fusion PhoA 8 6339478 Fusion PhoA 8 6339478 Fusion PhoA 2 6339478 Fusion PhoA 680 6339478 Fusion BAD yes 680 J Biol Chem 1996 Oct 11;271(41):25582-9 Positions are shifted by -1 No numerical data Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License cGMP-gated cation channel alpha 1 Bos taurus Q00194 MKKVIINTWH SFVNIPNVVG PDVEKEITRM ENGACSSFSG DDDDSASMFE ESETENPHAR DSFRSNTHGS GQPSQREQYL PGAIALFNVN NSSNKEQEPK EKKKKKKEKK SKPDDKNENK KDPEKKKKKE KDKDKKKKEE KGKDKKEEEK KEVVVIDPSG NTYYNWLFCI TLPVMYNWTM IIARACFDEL QSDYLEYWLA FDYLSDVVYL LDMFVRTRTG YLEQGLLVKE ERKLIDKYKS TFQFKLDVLS VIPTDLLYIK FGWNYPEIRL NRLLRISRMF EFFQRTETRT NYPNIFRISN LVMYIIIIIH WNACVYFSIS KAIGFGNDTW VYPDVNDPDF GRLARKYVYS LYWSTLTLTT IGETPPPVRD SEYFFVVADF LIGVLIFATI VGNIGSMISN MNAARAEFQA RIDAIKQYMH FRNVSKDMEK RVIKWFDYLW TNKKTVDERE VLKYLPDKLR AEIAINVHLD TLKKVRIFAD CEAGLLVELV LKLQPQVYSP GDYICKKGDI GREMYIIKEG KLAVVADDGI TQFVVLSDGS YFGEISILNI KGSKAGNRRT ANIKSIGYSD LFCLSKDDLM EALTEYPDAK GMLEEKGKQI LMKDGLLDIN IANAGSDPKD LEEKVTRMES SVDLLQTRFA RILAEYESMQ QKLKQRLTKV EKFLKPLIDT EFSAIEGSGT ESGPTDSTQD Plasma membrane;Cytoplasm;Extracellular 78 Immunolocalisation Epitope Insertion (EM epitope) Fusion PhoA 2766 290 1100846 Fusion LacZ 31.3 10.4 M1971 Fusion PhoA 4.1 2.5 1100846 Fusion LacZ 6791 657 M1971 Fusion PhoA yes 8.5 1100846 0.8 Opposit with the results of AP00302 and with the proposed topology Fusion LacZ yes 3670 M1971 103 Opposit with the results of AP00302 and with the proposed topology Fusion PhoA 7.3 2.7 1100846 Fusion LacZ 6966 1101 M1971 Fusion PhoA 5.9 1100846 0.5 Fusion LacZ 2536 M1971 73.0 Fusion PhoAS 6.9 1100846 10.0 Fusion PhoA 6.7 2.1 1100846 Fusion LacZ 3863 830 M1971 Fusion PhoA yes 5.0 1100846 0.8 Does not correspond to the proposed modell. Mutations D255V can invert the topology. Authors predict this position to be in extracellular. Fusion LacZ yes 1724 M1971 55.3 Does not correspond to the proposed modell. Mutations D255V can invert the topology. Authors predict this position to be in extracellular. Fusion PhoA 247 129 1100846 Fusion LacZ 18.9 6.7 M1971 Fusion PhoA 5.7 1100846 1.2 Fusion LacZ 1733 M1971 58.6 Fusion PhoA 246 76.3 1100846 Fusion LacZ 27.7 10.2 M1971 Immunolocalisation PostTransMod NGlyc Fusion PhoA 2461 1100846 390 Fusion PhoA 297 1100846 19.1 Fusion LacZ 295 M1971 18.5 Fusion PhoAS 112 1100846 8.0 Fusion PhoA 2.3 1100846 0.6 Fusion LacZ 4791 M1971 685 J Biol Chem 1992 Jan 5;267(1):644-8 No numerical data J Biol Chem 1991 Nov 15;266(32):21917-22 No numerical data Proc Natl Acad Sci U S A 1995 Aug 1;92(16):7425-9 No numerical data Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License ATP synthase A chain Escherichia coli P00855 Q47708 P0AB99 P0AB98 Q2M856 Q47065 N/A NMR fig 5 MASENMTPQD YIGHHLNNLQ LDLRTFSLVD PQNPPATFWT INIDSMFFSV VLGLLFLVLF RSVAKKATSG VPGKFQTAIE LVIGFVNGSV KDMYHGKSKL IAPLALTIFV WVFLMNLMDL LPIDLLPYIA EHVLGLPALR VVPSADVNVT LSMALGVFIL ILFYSIKMKG IGGFTKELTL QPFNHWAFIP VNLILEGVSL LSKPVSLGLR LFGNMYAGEL IFILIAGLLP WWSQWILNVP WAIFHILIIT LQAFIFMVLT IVYLSMASEE H Bacterial inner membrane;Cytoplasm;Periplasmic space 83 Protease Partial Proteolysis (Subs protease) Chemical_modification Cys Immunolocalisation Epitope Insertion Inside-out vesicle used in experiment Chemical_modification Cys Chemical_modification Cys Chemical_modification Cys Fusion PhoA yes less than 100 1100846 Chemical_modification Cys Other Revertants Fusion PhoA 5 6339478 Chemical_modification Cys Fusion PhoA less than 100 1100846 Chemical_modification Cys Chemical_modification Cys Chemical_modification Cys Chemical_modification Cys Fusion PhoA less than 100 1100846 Structure PDBTM Structure PDBTM Fusion PhoA more than 100 1100846 Fusion PhoA more than 100 1100846 Fusion PhoA 46 6339478 Fusion PhoA more than 100 1100846 Structure PDBTM Fusion PhoA more than 100 1100846 Chemical_modification Cys Chemical_modification Cys Chemical_modification Cys Fusion PhoA less than 100 1100846 Fusion PhoA less than 1 6339478 Fusion PhoA less than 100 1100846 Fusion PhoA less than 100 1100846 Fusion PhoA less than 1 6339478 Fusion PhoA less than 1 6339478 Fusion PhoA less than 100 1100846 Structure PDBTM Fusion PhoA less than 1 6339478 Fusion PhoA less than 100 1100846 Fusion PhoA less than 100 1100846 Structure PDBTM Fusion PhoA less than 100 1100846 Immunolocalisation Epitope Insertion Inside-out vesicle used in experiment Chemical_modification Cys Fusion PhoA less than 100 1100846 Chemical_modification Cys Fusion PhoA less than 100 1100846 Structure PDBTM Fusion PhoA more than 100 1100846 Fusion PhoA less than 1 6339478 Structure PDBTM Fusion PhoA less than 100 1100846 Other Revertants Fusion PhoA less than 100 1100846 Fusion PhoA less than 100 1100846 Fusion PhoA less than 100 1100846 Structure PDBTM Fusion PhoA 59 6339478 Chemical_modification Cys Fusion PhoA more than 100 1100846 Chemical_modification Cys Chemical_modification Cys Chemical_modification Cys Fusion PhoA more than 100 1100846 Fusion PhoA 27 6339478 Fusion PhoA more than 100 1100846 Fusion PhoA 30 6339478 Fusion PhoA 48 6339478 Fusion PhoA 30 6339478 Structure PDBTM Fusion PhoA more than 100 1100846 Fusion PhoA 6 6339478 Fusion PhoA less than 100 1100846 Immunolocalisation Epitope Insertion Inside-out vesicle used in experiment Fusion PhoA more than 100 1100846 Chemical_modification Cys Fusion PhoA 6 6339478 Chemical_modification Cys Structure PDBTM Fusion PhoA 11 6339478 Chemical_modification Cys Chemical_modification Cys Fusion PhoA more than 100 1100846 Proc Natl Acad Sci U S A 1992 Oct 15;89(20):9799-803 No numerical data FEBS Lett 1990 Jan 15;260(1):31-4 J Biol Chem 1990 Jun 25;265(18):10541-50 Positions are shifted by -1 Biochim Biophys Acta 1984 Apr 9;768(1):1-27 No numerical data FEBS Lett 1996 Jul 15;390(1):34-8 J Biol Chem 1998 Jun 26;273(26):16241-7 J Biol Chem 1999 Jun 11;274(24):17353-7 NMR structure Nature 1999 Nov 18;402(6759):263-8 NMR structure Partial sequence only Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Aquaporin Z Escherichia coli P60844 P48838 P75827 Q47159 2.50 XRAY This is followed by a loop from residue 103 to residue 131 that descends into the periplasmic vestibule and leads into the carboxy-terminal segment. M5–M8 reiterates the amino-terminal topology, except now beginning on the periplasmic and ending on the cytoplasmic side 3.20 XRAY Arg-189 points toward the periplasmic vestibule, 2.30 XRAY by similarity 2.20 XRAY by similarity 2.55 XRAY by similarity 1.90 XRAY by similarity 2.40 XRAY According to 20855585/Fig1 2.50 XRAY According to 20855585/Fig1 3.10 XRAY According to 20855585/Fig1 MFRKLAAECF GTFWLVFGGC GSAVLAAGFP ELGIGFAGVA LAFGLTVLTM AFAVGHISGG HFNPAVTIGL WAGGRFPAKE VVGYVIAQVV GGIVAAALLY LIASGKTGFD AAASGFASNG YGEHSPGGYS MLSALVVELV LSAGFLLVIH GATDKFAPAG FAPIAIGLAL TLIHLISIPV TNTSVNPARS TAVAIFQGGW ALEQLWFFWV VPIVGGIIGG LIYRTLLEKR D Bacterial inner membrane;Cytoplasm;Periplasmic space 95 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Protease Partial Proteolysis (Tryp protease) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Protease Partial Proteolysis (Tryp protease) Fusion PhoA 0.00 Fusion GFP 0.50 EMBO J 1999 Sep 15;18(18):4981-7 PLoS Biol. 2003 Dec;1(3):E72. Epub 2003 Dec 22. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. J Biol Chem. 2006 Jan 6;281(1):454-60. Epub 2005 Oct 20. J Mol Biol. 2007 May 4;368(3):607-17. Epub 2007 Mar 2. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17164-9. doi: Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sigma-K factor processing regulatory protein BOFA Bacillus subtilis P24282 MEPIFIIGII LGLVILLFLS GSAAKPLKWI GITAVKFVAG ALLLVCVNMF GGSLCIHVPI NLVTTAISGI LGIPGIAALV VIKQFII Bacterial inner membrane;Cytoplasm;Periplasmic space 83 Fusion PhoA 11 4298222 Fusion LacZ 180 M1971 Fusion PhoA 157 4298222 Fusion LacZ 12 M1971 Fusion PhoA 148 4298222 Fusion LacZ 22 M1971 Fusion PhoA 134 4298222 Fusion LacZ 12 M1971 Microbiology 1997 Apr;143 ( Pt 4):1053-8 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Alkane-1 monooxygenase Pseudomonas oleovorans P12691 MLEKHRVLDS APEYVDKKKY LWILSTLWPA TPMIGIWLAN ETGWGIFYGL VLLVWYGALP LLDAMFGEDF NNPPEEVVPK LEKERYYRVL TYLTVPMHYA ALIVSAWWVG TQPMSWLEIG ALALSLGIVN GLALNTGHEL GHKKETFDRW MAKIVLAVVG YGHFFIEHNK GHHRDVATPM DPATSRMGES IYKFSIREIP GAFIRAWGLE EQRLSRRGQS VWSFDNEILQ PMIITVILYA VLLALFGPKM LVFLPIQMAF GWWQLTSANY IEHYGLLRQK MEDGRYEHQK PHHSWNSNHI VSNLVLFHLQ RHSDHHAHPT RSYQSLRDFP GLPALPTGYP GAFLMAMIPQ WFRSVMDPKV VDWAGGDLNK IQIDDSMRET YLKKFGTSSA GHSSSTSAVA S Bacterial inner membrane;Cytoplasm;Periplasmic space 73 Fusion PhoA 2 1100846 Fusion LacZ 1760 M1971 Fusion PhoA 135 1100846 Fusion PhoA 15 1100846 Fusion LacZ 210 M1971 Fusion PhoA 720 1100846 Fusion LacZ 150 M1971 Fusion PhoA 12 1100846 Fusion LacZ 450 M1971 Fusion PhoA 25 1100846 Fusion LacZ 1630 M1971 Fusion PhoA 19 1100846 Fusion LacZ 880 M1971 Fusion PhoA 35 1100846 Fusion LacZ 190 M1971 Fusion PhoA 420 1100846 Fusion LacZ 45 M1971 Fusion PhoA 40 1100846 Fusion PhoA 25 1100846 Fusion PhoA 3 1100846 Fusion LacZ 810 M1971 Fusion PhoA 12 1100846 Fusion PhoA 2 1100846 Fusion LacZ 560 M1971 Fusion PhoA 2 1100846 Fusion LacZ 1560 M1971 Fusion PhoA 1 1100846 Fusion LacZ 1850 M1971 J Biol Chem 1992 May 5;267(13):9194-201 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License 5-hydroxytryptamine 3 receptor precursor Mus musculus P23979 Q61225 Q61226 3.50 XRAY According to 25119048/Fig1 MRLCIPQVLL ALFLSMLTAP GEGSRRRATQ EDTTQPALLR LSDHLLANYK KGVRPVRDWR KPTTVSIDVI MYAILNVDEK NQVLTTYIWY RQYWTDEFLQ WTPEDFDNVT KLSIPTDSIW VPDILINEFV DVGKSPNIPY VYVHHRGEVQ NYKPLQLVTA CSLDIYNFPF DVQNCSLTFT SWLHTIQDIN ITLWRSPEEV RSDKSIFINQ GEWELLEVFP QFKEFSIDIS NSYAEMKFYV IIRRRPLFYA VSLLLPSIFL MVVDIVGFCL PPDSGERVSF KITLLLGYSV FLIIVSDTLP ATIGTPLIGV YFVVCMALLV ISLAETIFIV RLVHKQDLQR PVPDWLRHLV LDRIAWILCL GEQPMAHRPP ATFQANKTDD CSGSDLLPAM GNHCSHVGGP QDLEKTPRGR GSPLPPPREA SLAVRGLLQE LSSIRHFLEK RDEMREVARD WLRVGYVLDR LLFRIYLLAV LAYSITLVTL WSIWHYS Plasma membrane;Cytoplasm;Extracellular 95 Structure PDBTM Structure PDBTM Chemical_modification Cys SSBond with Cys175 Chemical_modification Cys SSBond with Cys161 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Endogen Epitope Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion yes 1850 (FETcm epitope) Immunolocalisation Epitope Insertion yes 1850 (EI epitope) J Neurochem 1996 Mar;66(3):1027-32 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Nature. 2014 Aug 21;512(7514):276-81. doi: 10.1038/nature13552. Epub 2014 Aug 3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sulfonylurea receptor 1 Cricetus cricetus Q09427 PLAFCGTENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW GSQSSKVHIH HSTWLHFPGH NLRWILTFIL LFVLVCEIAE GILSDGVTES RHLHLYMPAG MAFMAAITSV VYYHNIETSN FPKLLIALLI YWTLAFITKT IKFVKFYDHA IGFSQLRFCL TGLLVILYGM LLLVEVNVIR VRRYIFFKTP REVKPPEDLQ DLGVRFLQPF VNLLSKGTYW WMNAFIKTAH KKPIDLRAIA KLPIAMRALT NYQRLCVAFD AQARKDTQSP QGARAIWRAL CHAFGRRLIL SSTFRILADL LGFAGPLCIF GIVDHLGKEN HVFQPKTQFL GVYFVSSQEF LGNAYVLAVL LFLALLLQRT FLQASYYVAI ETGINLRGAI QTKIYNKIMH MSTSNLSMGE MTAGQICNLV AIDTNQLMWF FFLCPNLWTM PVQIIVGVIL LYYILGVSAL IGAAVIILLA PVQYFVATKL SQAQRTTLEH SNERLKQTNE MLRGMKLLKL YAWESIFCSR VEVTRRKEMT SLRAFAVYTS ISIFMNTAIP IAAVLITFVG HVSFFKESDL SPSVAFASLS LFHILVTPLF LLSSVVRSTV KALVSVQKLS EFLSSAEIRE EQCAPREPAP QGQAGKYQAV PLKVVNRKRP AREEVRDLLG PLQRLAPSMD GDADNFCVQI IGGFFTWTPD GIPTLSNITI RIPRGQLTMI VGQVGCGKSS LLLATLGEMQ KVSGAVFWNS NLPDSEGEDP SSPERETAAG SDIRSRGPVA YASQKPWLLN ATVEENITFE SPFNKQRYKM VIEACSLQPD IDILPHGDQT QIGERGINLS GGQRQRISVA RALYQQTNVV FLDDPFSALD VHLSDHLMQA GILELLRDDK RTVVLVTHKL QYLPHADWII AMKDGTIQRE GTLKDFQRSE CQLFEHWKTL MNRQDQELEK ETVMERKASE PSQGLPRAMS SRDGLLLDEE EEEEEAAESE EDDNLSSVLH QRAKIPWRAC TKYLSSAGIL LLSLLVFSQL LKHMVLVAID YWLAKWTDSA LVLSPAARNC SLSQECDLDQ SVYAMVFTLL CSLGIVLCLV TSVTVEWTGL KVAKRLHRSL LNRIILAPMR FFETTPLGSI LNRFSSDCNT IDQHIPSTLE CLSRSTLLCV SALTVISYVT PVFLVALLPL AVVCYFIQKY FRVASRDLQQ LDDTTQLPLV SHFAETVEGL TTIRAFRYEA RFQQKLLEYT DSNNIASLFL TAANRWLEVC MEYIGACVVL IAAATSISNS LHRELSAGLV GLGLTYALMV SNYLNWMVRN LADMEIQLGA VKRIHALLKT EAESYEGLLA PSLIPKNWPD QGKIQIQNLS VRYDSSLKPV LKHVNTLISP GQKIGICGRT GSGKSSFSLA FFRMVDMFEG RIIIDGIDIA KLPLHTLRSR LSIILQDPVL FSGTIRFNLD PEKKCSDSTL WEALEIAQLK LVVKALPGGL DAIITEGGEN FSQGQRQLFC LARAFVRKTS IFIMDEATAS IDMATENILQ KVVMTAFADR TVVTIAHRVH TILSADLVMV LKRGAILEFD KPETLLSQKD SVFASFVRAD K Plasma membrane;Cytoplasm;Extracellular 90 Chemical_modification Cys PostTransMod NGlyc yes 1850 PostTransMod NGlyc PostTransMod NGlyc Chemical_modification Cys Fusion PL Chemical_modification Cys Fusion PL Fusion PL Chemical_modification Cys Fusion PL Fusion PL Fusion PL Fusion PL Chemical_modification Cys Immunolocalisation Epitope Insertion yes 1850 (EI epitope) Immunolocalisation Epitope Insertion yes 1850 (EI epitope) Chemical_modification Cys Other SeqMotif Walker A Other SeqMotif ABC Signature Other SeqMotif Walker B PostTransMod NGlyc yes 1850 Immunolocalisation Epitope Insertion yes 1850 (EI epitope) Chemical_modification Cys Immunolocalisation Epitope Insertion yes 1850 (EI epitope) Chemical_modification Cys Other SeqMotif Walker A Other SeqMotif ABC Signature Other SeqMotif Walker B Biochemistry. 1996 Nov 26;35(47):14793-9. J Biol Chem 1999 Oct 8;274(41):29122-9 No numerical data J Biol Chem 2001 Nov 2;276(44):41270-8 Reference for SeqMotif Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Aromatic amino acid transport protein aroP Escherichia coli P15993 P75650 MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL GYAIAGFIAF LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW VLYVLVAMAE LTAVGKYIQF WYPEIPTWVS AAVFFVVINA INLTNVKVFG EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG GPQATVSNLW DQGGFLPHAF TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ VIYRILIFYI GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI NYLAPESAFG LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL LYPLGNWICL LFMAAVLVIM LMTRGMAISV YLIPVWLIVL GIGYLFKEKT AKAVKAH Bacterial inner membrane;Cytoplasm;Periplasmic space 90 Fusion PhoAS 0.1 1943817 Fusion PhoAS 3 1943817 Fusion PhoAS 126 1943817 Fusion PhoAS 0.1 1943817 Fusion PhoAS 0.1 1943817 Fusion PhoAS 60 1943817 Fusion PhoAS 0.5 1943817 Fusion PhoAS 0.1 1943817 Fusion PhoAS 0.1 1943817 Fusion PhoAS 270 1943817 Fusion PhoAS 363 1943817 Fusion PhoAS 66 1943817 Fusion PhoAS 69 1943817 Fusion PhoAS 8 1943817 Fusion PhoAS 7 1943817 Fusion PhoAS 15 1943817 Fusion PhoAS yes 214 1943817 Fusion PhoAS 76 1943817 Fusion PhoAS 17 1943817 Fusion PhoAS 0.5 1943817 Fusion PhoAS yes 177 1943817 Fusion PhoAS 79 1943817 Fusion PhoAS 2 1943817 Fusion PhoAS yes 142 1943817 Fusion PhoAS 2 1943817 Fusion PhoA 0.00 Fusion GFP 1.07 J Bacteriol 1997 May;179(10):3317-23 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License 60 kDa inner-membrane protein Escherichia coli P25714 Q2M818 2.50 XRAY Crystal structure of the major periplasmic domain of the bacterial membrane protein assembly facilitator YidC. 1.80 XRAY The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC MDSQRNLLVI ALLFVSFMIW QAWEQDKNPQ PQAQQTTQTT TTAAGSAADQ GVPASGQGKL ISVKTDVLDL TINTRGGDVE QALLPAYPKE LNSTQPFQLL ETSPQFIYQA QSGLTGRDGP DNPANGPRPL YNVEKDAYVL AEGQNELQVP MTYTDAAGNT FTKTFVLKRG DYAVNVNYNV QNAGEKPLEI SSFGQLKQSI TLPPHLDTGS SNFALHTFRG AAYSTPDEKY EKYKFDTIAD NENLNISSKG GWVAMLQQYF ATAWIPHNDG TNNFYTANLG NGIAAIGYKS QPVLVQPGQT GAMNSTLWVG PEIQDKMAAV APHLDLTVDY GWLWFISQPL FKLLKWIHSF VGNWGFSIII ITFIVRGIMY PLTKAQYTSM AKMRMLQPKI QAMRERLGDD KQRISQEMMA LYKAEKVNPL GGCFPLLIQM PIFLALYYML MGSVELRQAP FALWIHDLSA QDPYYILPIL MGVTMFFIQK MSPTTVTDPM QQKIMTFMPV IFTVFFLWFP SGLVLYYIVS NLVTIIQQQL IYRGLEKRGL HSREKKKS Bacterial inner membrane;Cytoplasm;Periplasmic space 93 Structure PDB Structure PDB Fusion PhoA 66 1943817 Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Fusion PhoA 92 1943817 Structure PDB Structure PDB Structure PDB Structure PDB Fusion PhoA 197 1943817 Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Structure PDB Fusion PhoA 70 1943817 Fusion PhoA 6 1943817 Fusion PhoA 74 1943817 Fusion PhoA 6 1943817 Fusion PhoA 160 1943817 Fusion PhoA 42 1943817 Fusion PhoA 42 1943817 Fusion PhoA 9 1943817 Fusion PhoA 17 1943817 J Biol Chem 1998 Nov 13;273(46):30415-8 J Biol Chem. 2008 Feb 22;283(8):5208-16. Epub 2007 Dec 19. J Biol Chem. 2008 Apr 4;283(14):9350-8. doi: 10.1074/jbc.M710493200. Epub 2008 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License ADP,ATP carrier protein 2 Saccharomyces cerevisiae P18239 D6VPW9 2.49 XRAY by similarity 3.20 XRAY by similarity MSSNAQVKTP LPPAPAPKKE SNFLIDFLMG GVSAAVAKTA ASPIERVKLL IQNQDEMLKQ GTLDRKYAGI LDCFKRTATQ EGVISFWRGN TANVIRYFPT QALNFAFKDK IKAMFGFKKE EGYAKWFAGN LASGGAAGAL SLLFVYSLDY ARTRLAADSK SSKKGGARQF NGLIDVYKKT LKSDGVAGLY RGFLPSVVGI VVYRGLYFGM YDSLKPLLLT GSLEGSFLAS FLLGWVVTTG ASTCSYPLDT VRRRMMMTSG QAVKYDGAFD CLRKIVAAEG VGSLFKGCGA NILRGVAGAG VISMYDQLQM ILFGKKFK Mitochondrial inner membrane;Matrix;Inter membrane space 89 Structure PDBTM Structure PDBTM Other Revertants Structure PDBTM Structure PDBTM Other Revertants Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other Revertants Other Revertants Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other Revertants Structure PDBTM Other Revertants Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other Revertants Other Revertants Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other Revertants Other Revertants Other Revertants Structure PDBTM Structure PDBTM Other Revertants Structure PDBTM J Mol Biol 1993 Apr 20;230(4):1171-82 J Mol Biol 1993 Apr 20;230(4):1159-70 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E426-34. doi: Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Aquaporin-CHIP Homo sapiens P29972 B5BU39 E7EM69 E9PC21 F5GY19 Q8TBI5 Q8TDC1 3.80 ERAY >>The short N terminus of AQP1 is located on the cytoplasmic side of the membrane<< (11034202) 3.54 ERAY by similarity 3.70 ERAY by similarity MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA QCVGAIVATA ILSGITSSLT GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD RVKVWTSGQV EEYDLDADDI NSRVEMKPK Plasma membrane;Cytoplasm;Extracellular 96 Immunolocalisation Epitope Insertion (FETcm epitope) Immunolocalisation Epitope Insertion Inside-out vesicle used in experiment Immunolocalisation Epitope Insertion yes 17 (EI epitope) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM PostTransMod NGlyc yes 17 PostTransMod NGlyc Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Structure PDBTM PostTransMod NGlyc Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion yes 17 (EI epitope) Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion yes 17 (EI epitope) Structure PDBTM Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion yes 17 (EI epitope) Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Chemical_modification Cys yes 17 Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion yes 17 (EI epitope) Structure PDBTM Structure PDBTM Structure PDBTM PostTransMod NGlyc Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Immunolocalisation Epitope Insertion Inside-out vesicle used in experiment Structure PDBTM Structure PDBTM Structure PDBTM Fusion PL Immunolocalisation Epitope Insertion yes 17 (EI epitope) J Biol Chem 1991 Apr 5;266(10):6407-15 No numerical data J Biol Chem 1994 Jan 21;269(3):1668-73 J Cell Biol 1994 May;125(4):803-15 J Biol Chem 1993 Jan 5;268(1):17-20 No numerical data J Cell Biol 1993 Jan;120(2):371-83 No numerical data Nature 1997 Jun 5;387(6633):627-30. J Struct Biol 2000 May;130(1):45-53. J Mol Biol 2000 Jul 21;300(4):987-94. J Mol Biol 2000 Aug 11;301(2):369-87. Nature 2000 Oct 5;407(6804):599-605 Based on ERAY structure Proc Natl Acad Sci U S A 2001 Feb 13;98(4):1398-403. Epub 2001 Jan 30. FEBS Lett 2001 Aug 31;504(3):206-11. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Arsenical pump membrane protein Escherichia coli P37310 P76708 P0AB94 P0AB93 Q2M7G4 P0AB95 MLLAGAIFVL TIVLVIWQPK GLGIGWSATL GAVLALVTGV VHPGDIPVVW NIVWNATAAF IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL LGAAVAALFA NDGAALILTP IVIAMLLALG FSKGTTLAFV MAAGFIADTA SLPLIVSNLV NIVSADFFGL GFREYASVMV PVDIAAIVAT LVMLHLYFRK DIPQNYDMAL LKSPAEAIKD PATFKTGWVV LLLLLVGFFV LEPLGIPVSA IAAVGALILF VVAKRGHAIN TGKVLRGAPW QIVIFSLGMY LVVYGLRNAG LTEYLSGVLN VLADNGLWAA TLGTGFLTAF LSSIMNNMPT VLVGALSIDG STASGVIKEA MVYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG YYFRTGIIMT LPVLFVTLAA LALRLSFTL Bacterial inner membrane;Cytoplasm;Periplasmic space 69 Fusion PhoA 43.5 1100846 Fusion PhoA 134.0 1100846 Fusion PhoA 129.8 1100846 Fusion LacZ 0.5 M1971 Fusion LacZ 1.7 M1971 Fusion BlaM more than 600 Fusion PhoA 53.8 1100846 Fusion BlaM 20 Fusion BlaM 4 Fusion BlaM 160 Fusion BlaM 4 Fusion BlaM 5 Fusion LacZ 26.2 M1971 Fusion PhoA 3.4 1100846 Fusion LacZ 0.5 M1971 Fusion LacZ 1.2 M1971 Fusion BlaM 120 Fusion BlaM 4 Fusion BlaM Unknown Fusion BlaM 4 Fusion LacZ 48.9 M1971 Protease Partial Proteolysis (V8 protease) Fusion LacZ 42.6 M1971 Fusion BlaM 20 Fusion PhoA 1.32 Fusion GFP 0.01 J Biol Chem 1992 Jun 25;267(18):12570-6 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Potassium-transporting ATPase alpha chain Oryctolagus cuniculus P27112 MGKADNYELY SVELGPGPGG DMAAKMSKKK KAGGGGGKRK EKLENMKKEM EINDHQLSVA ELEQKYQTSA TKGLSARLAA ELLLRDGPNA LRPPRGTPEY VKFARQLAGG LQCLMWVAAA ICLIAFAIQA SEGDLTTDDN LYLALALIAV VVVTGCFGYY QEFKSTNIIA SFKNLVPQQA TVIRDGDKFQ INADQLVVGD LVEMKGGDRV PADIRILAAQ GCKVDNSSLT GESEPQTRSP ECTHESPLET RNIAFFSTMC LEGTAQGLVV NTGDRTIIGR IASLASGVEN EKTPIAIEIE HFVDIIAGLA ILFGATFFVV AMCIGYTFLR AMVFFMAIVV AYVPEGLLAT VTVCLSLTAK RLASKNCVVK NLEAVETLGS TSVICSDKTG TLTQNRMTVS HLWFDNHIHT ADTTEDQSGQ TFDQSSETWR ALCRVLTLCN RAAFKSGQDA VPVPKRIVIG DASETALLKF SELTLGNAMG YRDRFPKVCE IPFNSTNKFQ LSIHTLEDPR DPRHLLVMKG APERVLERCS SILIKGQELP LDEQWREAFQ TAYLSLGGLG ERVLGFCHLY LSEKDYPPGY AFDVEAMNFP SSGLCFAGLV SMIDPPRATV PDAVLKCRTA GIRVIMVTGD HPITAKAIAA SVGIISEGSE TVEDIAARLR VPVDQVNRKD ARACVINGMQ LKDMDPSELV EALRTHPEMV FARTSPQQKL VIVESCQRLG AIVAVTGDGV NDSPALKKAD IGVAMGIAGS DAAKNAADMI LLDDNFASIV TGVEQGRLIF DNLKKSIAYT LTKNIPELTP YLIYITVSVP LPLGCITILF IELCTDIFPS VSLAYEKAES DIMHLRPRNP KRDRLVNEPL AAYSYFQIGA IQSFAGFTDY FTAMAQEGWF PLLCVGLRPQ WEDHHLQDLQ DSYGQEWTFG QRLYQQYTCY TVFFISIEMC QIADVLIRKT RRLSAFQQGF FRNRILVIAI VFQVCIGCFL CYCPGMPNIF NFMPIRFQWW LVPMPFGLLI FVYDEIRKLG VRCCPGSWWD QELYY Plasma membrane;Cytoplasm;Extracellular 96 Other Tailoring M0M1 Other Tailoring M0M1 Other Tailoring M0M1 Other Tailoring M0M1 Other Tailoring M0M1 Other Tailoring yes M0M1 Experiment for region M5-M6 (777-853) shows no membraneous region, as well as for M7 (846-897), but according to other constructions there should be one transmembrane region. Protease Partial Proteolysis (Tryp protease) Protease Partial Proteolysis (Tryp protease) Immunolocalisation Other Tailoring M0M1 Other Tailoring M0M1 Protease Partial Proteolysis (Tryp protease) Other Tailoring M0M1 Protease Partial Proteolysis (CarbY protease) Biochim Biophys Acta 1992 May 7;1131(1):69-77 Biochim Biophys Acta 1992 Dec 9;1112(2):246-50 No numerical data Curr Opin Cell Biol 1991 Aug;3(4):685-94 J Biol Chem 1994 Jun 17;269(24):16909-19 No numerical data Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Beta-1 adrenergic receptor Meleagris gallopavo P07700 2.7 XRAY by similarity 2.50 XRAY According to 18594507/Fig1 2.60 XRAY According to 18594507/Fig1 2.60 XRAY According to 18594507/Fig1 2.85 XRAY According to 18594507/Fig1 3.05 XRAY According to 18594507/Fig1 3.00 XRAY 21540331 ("Arg139 and Glu285 linking the cytoplasmic ends of transmembrane helices 3 and 6") 3.25 XRAY 21540331 ("Arg139 and Glu285 linking the cytoplasmic ends of transmembrane helices 3 and 6") 3.15 XRAY 21540331 ("Arg139 and Glu285 linking the cytoplasmic ends of transmembrane helices 3 and 6") 3.65 XRAY 21540331 ("Arg139 and Glu285 linking the cytoplasmic ends of transmembrane helices 3 and 6") 2.80 XRAY by similarity 2.70 XRAY by similarity 3.20 XRAY According to 22579251/Fig2 2.30 XRAY According to 22579251/Fig2 2.10 XRAY According to 24663151/S2 3.50 XRAY by similarity MGDGWLPPDC GPHNRSGGGG ATAAPTGSRQ VSAELLSQQW EAGMSLLMAL VVLLIVAGNV LVIAAIGRTQ RLQTLTNLFI TSLACADLVM GLLVVPFGAT LVVRGTWLWG SFLCECWTSL DVLCVTASIE TLCVIAIDRY LAITSPFRYQ SLMTRARAKV IICTVWAISA LVSFLPIMMH WWRDEDPQAL KCYQDPGCCD FVTNRAYAIA SSIISFYIPL LIMIFVYLRV YREAKEQIRK IDRCEGRFYG SQEQPQPPPL PQHQPILGNG RASKRKTSRV MAMREHKALK TLGIIMGVFT LCWLPFFLVN IVNVFNRDLV PDWLFVFFNW LGYANSAFNP IIYCRSPDFR KAFKRLLCFP RKADRRLHAG GQPAPLPGGF ISTLGSPEHS PGGTWSDCNG GTRGGSESSL EERHSKTSRS ESKMEREKNI LATTRFYCTF LGNGDKAVFC TVLRIVKLFE DATCTCPHTH KLKMKWRFKQ HQA Plasma membrane;Cytoplasm;Extracellular 96 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Proc Natl Acad Sci U S A 1986 Sep;83(18):6795-9 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):877-82. doi: Nature. 2008 Jul 24;454(7203):486-91. doi: 10.1038/nature07101. Epub 2008 Jun 25. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8228-32. doi: Structure. 2012 May 9;20(5):841-9. doi: 10.1016/j.str.2012.03.014. Nat Struct Mol Biol. 2013 Apr;20(4):419-25. doi: 10.1038/nsmb.2504. Epub 2013 Feb J Med Chem. 2013 May 9;56(9):3446-55. doi: 10.1021/jm400140q. Epub 2013 Apr 9. PLoS One. 2014 Mar 24;9(3):e92727. doi: 10.1371/journal.pone.0092727. eCollection Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License CD81 antigen Homo sapiens P18582 P60033 Q5U0J6 P60034 2.60 XRAY large extracellular loop of human CD81 MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTNLLYLELG DKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVVDDDA NNAKAVVKTF HETLDCCGSS TLTALTTSVL KNNLCPSGSN IISNLFKEDC HQKIDDLFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY Plasma membrane;Cytoplasm;Extracellular 93 Protease Partial Proteolysis (ProtK protease) Protease Partial Proteolysis (ProtK protease) Structure PDBTM Structure PDBTM Protease Partial Proteolysis (ProtK protease) J Biol Chem 1991 Aug 5;266(22):14597-602 Biol Chem. 2002 Sep;383(9):1447-52. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Complement component C9 precursor Homo sapiens P02748 MSACRSFAVA ICILEISILT AQYTTSYDPE LTESSGSASH IDCRMSPWSE WSQCDPCLRQ MFRSRSIEVF GQFNGKRCTD AVGDRRQCVP TEPCEDAEDD CGNDFQCSTG RCIKMRLRCN GDNDCGDFSD EDDCESEPRP PCRDRVVEES ELARTAGYGI NILGMDPLST PFDNEFYNGL CNRDRDGNTL TYYRRPWNVA SLIYETKGEK NFRTEHYEEQ IEAFKSIIQE KTSNFNAAIS LKFTPTETNK AEQCCEETAS SISLHGKGSF RFSYSKNETY QLFLSYSSKK EKMFLHVKGE IHLGRFVMRN RDVVLTTTFV DDIKALPTTY EKGEYFAFLE TYGTHYSSSG SLGGLYELIY VLDKASMKRK GVELKDIKRC LGYHLDVSLA FSEISVGAEF NKDDCVKRGE GRAVNITSEN LIDDVVSLIR GGTRKYAFEL KEKLLRGTVI DVTDFVNWAS SINDAPVLIS QKLSPIYNLV PVKMKNAHLK KQNLERAIED YINEFSVRKC HTCQNGGTVI LMDGKCLCAC PFKFEGIACE ISKQKISEGL PALEFPNEK Plasma membrane;Cytoplasm;Extracellular 80 PostTransMod Cman PostTransMod Cman PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc Protease TID Chemical_modification Cys SSBond with Cys405 Chemical_modification Cys SSBond with Cys380 PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc PostTransMod NGlyc Mol Immunol 1990 Jul;27(7):589-602 EMBO J 1985 Feb;4(2):375-82 J Biol Chem. 1985 Nov 25;260(27):14802-9. J Biol Chem 1999 Nov 12;274(46):32786-94 No numerical data Proteomics. 2004 Feb;4(2):454-65. Mol Cell Proteomics. 2006 Feb;5(2):226-33. Epub 2005 Oct 31. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. Mol Cell Proteomics. 2009 May;8(5):913-23. doi: 10.1074/mcp.M800504-MCP200. Epub J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cadmium, zinc and cobalt transporting ATPase Helicobacter pylori Q59465 MQEYHIHNLD CPDCASKLER DLNELDYVKK AQINFSTSKL FLDTSDFEKV KAFIKQNEPH LSLSFKEATE KPLSFTPLII TIMVFLGAIL ILHLNPSPLI EKAMFFVLAL VYLVSGKDVI LGAFRGLRKG QFFDENALML IATIAAFFVG AYEESVSIMV FYSAGEFLQK LAVSRSKKSL KALVDVAPNL AYLKKGDELV SVAPEDLRVN DIVVVKVGEK VPVDGVVVKG ESLLDERALS GESMPVNVSE NSKVLGGSLN LKAVLEIQVE KMYKDSSIAK VVDLVQQATN EKSETEKFIT KFSRYYTPSV LFIALMIAVL PPLFSMGSFD EWIYRGLVAL MVSCPCALVI SVPLGYFGGV GAASRKGILM KGVHVLEVLT QAKSIAFDKT GTLTKGVFKV TDIVPQNGHS KEEVLHYASC SQLLSTHPIA LSIQKACEEM LKDDKHQHDI KNYEEVSGMG VKAQCHTDLI IAGNEKMLDQ FHIAHSPSKE NGTIVHVAFN QTYVGYIVIS DEIKDDAIEC LRDLKVQGIE NFCILSGDRK SATESIAQTL GCEYHASLLP EEKTSVFKTF KERYKAPAIF VGDGINDAPT LASADVGIGM GKGSELSKQS ADIVITNDSL NSLVKVLAIA KKTKSIIWQN ILFALGIKAV FIVLGLMGVA SLWEAVFGDV GVTLLALANS MRAMRA Bacterial inner membrane;Cytoplasm;Periplasmic space 94 Fusion PhoA 3.4 6339478 Other Tailoring M0M1 Other Tailoring M0M1 Fusion PhoA 26.7 6339478 Other Tailoring M0M1 Fusion PhoA 3.6 6339478 Other Tailoring M0M1 Fusion PhoA 46.0 6339478 Fusion PhoA 6.5 6339478 Other Tailoring M0M1 Fusion PhoA 44.3 6339478 Other Tailoring M0M1 Other SeqMotif ATP-Binding Other SeqMotif ATP-Binding Fusion PhoA 5.7 6339478 Other Tailoring M0M1 Other Tailoring M0M1 Fusion PhoA 32.4 6339478 Fusion PhoA 6.9 6339478 J Biol Chem 1996 Jan 5;271(1):446-57 Res Microbiol 1999 Oct;150(8):507-20 Reference for SeqMotif Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Magnesium and cobalt transport protein corA Salmonella typhimurium P31138 P0A2R9 P0A2R8 MLSAFQLEKN RLTRLEVEES QSLIDAVWVD LVEPDDDERL RVQSELGQSL ATRPELEDIE ASARFFEDED GLHIHSFFFF EDAEDHAGNS TVAFTIRDGR LFTLRERELP AFRLYRMRAR SQAMVDGNAY ELLLDLFETK IEQLADEIEN IYSDLEKLSR VIMEGHQGDE YDEALSTLAE LEDIGWKVRL CLMDTQRALN FLVRKARLPG GQLEQAREIL RDIESLLPHN ESLFQKVNFL MQAAMGFINI EQNRIIKIFS VVSVVFLPPT LVASSYGMNF EFMPELKWSF GYPGAIIFMI LAGLAPYLYF KRKNWL Bacterial inner membrane;Cytoplasm;Periplasmic space 98 Fusion BlaM yes Fusion BlaM yes Fusion BlaM yes Fusion BlaM yes Fusion BlaM Fusion LacZ Fusion BlaM Fusion BlaM Fusion LacZ Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM yes 6.9 Fusion LacZ J Biol Chem 1993 Jul 5;268(19):14071-80 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Carnitine O-palmitoyltransferase I, mitochondrial liver isoform Rattus norvegicus P32198 P97780 Q6IMZ4 MAEAHQAVAF QFTVTPDGID LRLSHEALKQ ICLSGLHSWK KKFIRFKNGI ITGVFPANPS SWLIVVVGVI SSMHAKVDPS LGMIAKISRT LDTTGRMSSQ TKNIVSGVLF GTGLWVAVIM TMRYSLKVLL SYHGWMFAEH GKMSRSTKIW MAMVKVLSGR KPMLYSFQTS LPRLPVPAVK DTVSRYLESV RPLMKEEDFQ RMTALAQDFA VNLGPKLQWY LKLKSWWATN YVSDWWEEYI YLRGRGPLMV NSNYYAMEML YITPTHIQAA RAGNTIHAIL LYRRTLDREE LKPIRLLGST IPLCSAQWER LFNTSRIPGE ETDTIQHIKD SRHIVVYHRG RYFKVWLYHD GRLLRPRELE QQMQQILDDP SEPQPGEAKL AALTAADRVP WAKCRQTYFA RGKNKQSLDA VEKAAFFVTL DESEQGYREE DPEASIDSYA KSLLHGRCFD RWFDKSITFV VFKNSKIGIN AEHSWADAPI VGHLWEYVMA TDVFQLGYSE DGHCKGDTNP NIPKPTRLQW DIPGECQEVI DASLSSASLL ANDVDLHSFP FDSFGKGLIK KCRTSPDAFI QLALQLAHYK DMGKFCLTYE ASMTRLFREG RTETVRSCTM ESCNFVQAMM DPKSTAEQRL KLFKIACEKH QHLYRLAMTG AGIDRHLFCL YVVSKYLAVD SPFLKEVLSE PWRLSTSQTP QQQVELFDFE KNPDYVSCGG GFGPVADDGY GVSYIIVGEN FIHFHISSKF SSPETDSHRF GKHLRQAMMD IITLFGLTIN SKK Mitochondrial outer membrane;Inter membrane space;Cytoplasm 60 Immunolocalisation Immunolocalisation Immunolocalisation Biochem J 1997 May 1;323 ( Pt 3):711-8 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Gap junction alpha-1 protein Rattus norvegicus P08050 Q53ZE1 N/A NMR Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. GDWSALGKLL DKVQAYSTAG GKVWLSVLFI FRILLLGTAV ESAWGDEQSA FRCNTQQPGC ENVCYDKSFP ISHVRFWVLQ IIFVSVPTLL YLAHVFYVMR KEEKLNKKEE ELKVAQTDGV NVEMHLKQIE IKKFKYGIEE HGKVKMRGGL LRTYIISILF KSVFEVAFLL IQWYIYGFSL SAVYTCKRDP CPHQVDCFLS RPTEKTIFII FMLVVSLVSL ALNIIELFYV FFKGVKDRVK GRSDPYHATT GPLSPSKDCG SPKYAYFNGC SSPTAPLSPM SPPGYKLVTG DRNNSSCRNY NKQASEQNWA NYSAEQNRMG QAGSTISNSH AQPFDFPDDN QNAKKVAAGH ELQPLAIVDQ RPSSRASSRA SSRPRPDDLE I Plasma membrane;Cytoplasm;Extracellular 95 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Structure PDBTM Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 Immunolocalisation yes 6.9 J Mol Biol 1992 Feb 20;223(4):929-48 J Membr Biol 1990 May;115(3):229-40 J Cell Sci 1990 Sep;97 ( Pt 1):109-17 J Cell Biol 1989 Jun;108(6):2241-54 J Cell Biol 1989 Feb;108(2):595-605 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. J Biol Chem. 2004 Dec 24;279(52):54695-701. Epub 2004 Oct 18. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Gap junction beta-1 protein Homo sapiens P08034 B2R8R2 D3DVV2 Q5U0S4 N/A MODEL fig 2 MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS FICNTLQPGC NSVCYDQFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH IEKKMLRLEG HGDPLHLEEV KRHKVHISGT LWWTYVISVV FRLLFEAVFM YVFYLLYPGY AMVRLVKCDV YPCPNTVDCF VSRPTEKTVF TVFMLAASGI CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS PEYKQNEINK LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC Plasma membrane;Cytoplasm;Extracellular 97 Immunolocalisation Structure PDBTM Structure PDBTM Immunolocalisation Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Protease Partial Proteolysis (LysC protease) Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Protease Partial Proteolysis (LysC protease) Protease Partial Proteolysis (LysC protease) EMBO J 1988 Oct;7(10):2967-75 Based on ERAY structure Nature 1984 Feb 16-22;307(5952):609-13 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Mol Cell. 2004 Sep 24;15(6):879-88. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Gap junction beta-1 protein Rattus norvegicus P08033 MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS FICNTLQPGC NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH IEKKMLRLEG HGDPLHLEEV KRHKVHISGT LWWTYVISVV FRLLFEAVFM YVFYLLYPGY AMVRLVKCEA FPCPNTVDCF VSRPTEKTVF TVFMLAASGI CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS PEYKQNEINK LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC Plasma membrane;Cytoplasm;Extracellular 97 Immunolocalisation Immunolocalisation Chemical_modification Cys SSBond with region 166-177 Immunolocalisation Protease Partial Proteolysis (Tryp protease) Protease Partial Proteolysis (Lys-X protease) Protease Partial Proteolysis (Tryp protease) Immunolocalisation Chemical_modification Cys SSBond with region 53-64 Protease Partial Proteolysis (Arg-X protease) Protease Partial Proteolysis (Tryp protease) Protease Partial Proteolysis (Tryp protease) Immunolocalisation J Cell Sci 1991 Nov;100 ( Pt 3):567-78 J Biol Chem 1987 Jun 5;262(16):7751-63 No numerical prediction Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cytochrome B Rhodobacter sphaeroides Q02761 3.20 XRAY According to fig 1 (16924113) 3.10 XRAY According to 18039651/Fig1 2.60 XRAY According to 18039651/Fig1 2.40 XRAY According to 18039651/Fig1 SGIPHDHYEP RTGIEKWLHS RLPIVALAYD TIMIPTPRNL NWMWIWGVVL AFCLVLQIVT GIVLAMHYTP HVDLAFASVE HIMRNVNGGF MLRYLHANGA SLFFIAVYLH IFRGLYYGSY KAPREVTWIV GMLIYLAMMA TAFMGYVLPW GQMSFWGATV ITGLFGAIPG IGHSIQTWLL GGPAVDNATL NRFFSLHYLL PFVIAALVAI HIWAFHSTGN NNPTGVEVRR TSKAEAQKDT VPFWPYFIIK DVFALAVVLL VFFAIVGFMP NYLGHPDNYI EANPLSTPAH IVPEWYFLPF YAILRAFTAD VWVVQIANFI SFGIIDAKFF GVLAMFGAIL VMALVPWLDT SPVRSGRYRP MFKIYFWLLA ADFVILTWVG AQQTTFPYDW ISLIASAYWF AYFLVILPIL GAIEKPVAPP ATIEEDFNAH YSPATGGTKT VVAE Bacterial inner membrane;Cytoplasm;Periplasmic space 92 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 33 1100846 Fusion PhoA 40 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 32 1100846 Fusion PhoA 23 1100846 Fusion PhoA 35 1100846 Fusion PhoA 54 1100846 Fusion PhoA 24 1100846 Fusion PhoA 24 1100846 Fusion PhoA 21 1100846 Structure PDBTM Structure PDBTM Fusion PhoA 10 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 29 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 45 1100846 Fusion PhoA 49 1100846 Structure PDBTM Fusion PhoA 21 1100846 Fusion PhoA 21 1100846 Fusion PhoA 37 1100846 Fusion PhoA 29 1100846 Fusion PhoA yes 4 1100846 Problem with the proposed modell Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 9 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 8 1100846 Fusion PhoA 4 1100846 Fusion PhoA 7 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 5 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 43 1100846 Fusion PhoA 36 1100846 Fusion PhoA 36 1100846 Fusion PhoA 19 1100846 Fusion PhoA 34 1100846 Fusion PhoA 30 1100846 Fusion PhoA 45 1100846 Fusion PhoA 36 1100846 Fusion PhoA 22 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 46 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM J Biol Chem 1991 Jun 15;266(17):10967-73 Positions are shifted by -1 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13045-50. Epub 2006 Aug 21. J Biol Chem. 2008 Feb 1;283(5):2846-57. Epub 2007 Nov 26. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cytochrome D ubiquinol oxidase subunit I Escherichia coli P11026 P75754 P76823 P0ABK0 P0ABJ9 P0ABK1 MLDIVELSRL QFALTAMYHF LFVPLTLGMA FLLAIMETVY VLSGKQIYKD MTKFWGKLFG INFALGVATG LTMEFQFGTN WSYYSHYVGD IFGAPLAIEG LMAFFLESTF VGLFFFGWDR LGKVQHMCVT WLVALGSNLS ALWILVANGW MQNPIASDFN FETMRMEMVS FSELVLNPVA QVKFVHTVAS GYVTGAMFIL GISAWYMLKG RDFAFAKRSF AIAASFGMAA VLSVIVLGDE SGYEMGDVQK TKLAAIEAEW ETQPAPAAFT LFGIPDQEEE TNKFAIQIPY ALGIIATRSV DTPVIGLKEL MVQHEERIRN GMKAYSLLEQ LRSGSTDQAV RDQFNSMKKD LGYGLLLKRY TPNVADATEA QIQQATKDSI PRVAPLYFAF RIMVACGFLL LAIIALSFWS VIRNRIGEKK WLLRAALYGI PLPWIAVEAG WFVAEYGRQP WAIGEVLPTA VANSSLTAGD LIFSMVLICG LYTLFLVAEL FLMFKFARLG PSSLKTGRYH FEQSSTTTQP AR Bacterial inner membrane;Cytoplasm;Periplasmic space 84 Fusion PhoA 6 1100846 Fusion PhoA 100% 1100846 Fusion PhoA 97 1100846 Fusion PhoA 359 1100846 Fusion PhoA 275 1100846 Fusion PhoA 157 1100846 Fusion PhoA 73 1100846 Fusion PhoA 26% 1100846 Fusion PhoA 453 1100846 Fusion LacZ yes Fusion PhoA 72 1100846 Fusion PhoA 17 1100846 Fusion PhoA 53 1100846 Fusion PhoA 53 1100846 Fusion PhoA 13% 1100846 Fusion PhoA 1 1100846 Fusion PhoA 1 1100846 Immunolocalisation Fusion PhoA 153 1100846 Fusion PhoA 469 1100846 Fusion PhoA 866 1100846 Protease Partial Proteolysis (ChyT protease) Fusion PhoA 626 1100846 Fusion PhoA 406% 1100846 Fusion PhoA 368 1100846 Protease Partial Proteolysis (Tryp protease) Fusion LacZ yes Fusion PhoA 467 1100846 Fusion PhoA 750 1100846 Fusion PhoA 954 1100846 Fusion PhoA 694 1100846 Fusion PhoA 474 1100846 Fusion PhoA 528 1100846 Fusion PhoA 58 1100846 Fusion PhoA 26 1100846 Fusion LacZ Fusion LacZ yes Fusion PhoA 253 1100846 Fusion PhoA 510 1100846 Fusion PhoA 160% 1100846 Fusion LacZ Fusion LacZ Fusion LacZ Fusion PhoA 0.00 Fusion GFP 0.94 J Biol Chem 1990 Mar 15;265(8):4273-7 Biochemistry 1991 Apr 9;30(14):3401-6 Mol Microbiol 1991 Oct;5(10):2511-8 Alkaline phosphatase activities are not correlate with transmembrane topology especially in the medium range. These data should be omitted, therefore no localisation and sloc field filled out. J Biol Chem 1988 Sep 15;263(26):13130-7 FEBS Lett. 2004 Mar 12;561(1-3):58-62. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cytochrome D ubiquinol oxidase subunit II Escherichia coli P11027 P0ABK4 P0ABK3 P0ABK2 MIDYEVLRFI WWLLVGVLLI GFAVTDGFDM GVGMLTRFLG RNDTERRIMI NSIAPHWDGN QVWLITAGGA LFAAWPMVYA AAFSGFYVAM ILVLASLFFR PVGFDYRSKI EETRWRNMWD WGIFIGSFVP PLVIGVAFGN LLQGVPFNVD EYLRLYYTGN FFQLLNPFGL LAGVVSVGMI ITQGATYLQM RTVGELHLRT RATAQVAALV TLVCFALAGV WVMYGIDGYV VKSTMDHYAA SNPLNKEVVR EAGAWLVNFN NTPILWAIPA LGVVLPLLTI LTARMDKAAW AFVFSSLTLA CIILTAGIAM FPFVMPSSTM MNASLTMWDA TSSQLTLNVM TWVAVVLVPI ILLYTAWCYW KMFGRITKED IERNTHSLY Bacterial inner membrane;Cytoplasm;Periplasmic space 80 Fusion PhoA 1284 1100846 Fusion PhoA 100% 1100846 Fusion PhoA 163 1100846 Fusion PhoA 14% 1100846 Fusion PhoA 68 1100846 Fusion PhoA 41 1100846 Fusion PhoA 3% 1100846 Fusion LacZ yes Fusion PhoA 38 1100846 Fusion PhoA 14 1100846 Fusion PhoA 144 1100846 Fusion LacZ Fusion PhoA 178 1100846 Fusion PhoA 76 1100846 Fusion PhoA 93 1100846 Fusion PhoA 5% 1100846 Fusion PhoA 2 1100846 Fusion PhoA 23 1100846 Fusion PhoA 6% 1100846 Fusion PhoA 21 1100846 Fusion LacZ Fusion LacZ yes Fusion PhoA 5 1100846 Fusion LacZ Fusion PhoA 1320 1100846 Fusion PhoA 149 1100846 Fusion PhoA 917 1100846 Fusion PhoA 953 1100846 Fusion PhoA 981 1100846 Fusion PhoA 628 1100846 Fusion PhoA 5 1100846 Fusion LacZ Fusion PhoA 0.00 Fusion GFP 1.82 Mol Microbiol 1991 Oct;5(10):2511-8 Alkaline phosphatase activities are not correlate with transmembrane topology especially in the medium range. These data should be omitted, therefore no localisation and sloc field filled out. J Biol Chem 1988 Sep 15;263(26):13130-7 FEBS Lett. 2004 Mar 12;561(1-3):58-62. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Ubiquinol oxidase polypeptide II precursor Escherichia coli P18400 P0ABJ2 P0ABJ1 Q2MBZ4 2.5 XRAY Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex. 2.3 XRAY Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex. 3.50 XRAY fig 3 MRLRKYNKSL GWLSLFAGTV LLSGCNSALL DPKGQIGLEQ RSLILTAFGL MLIVVIPAIL MAVGFAWKYR ASNKDAKYSP NWSHSNKVEA VVWTVPILII IFLAVLTWKT THALEPSKPL AHDEKPITIE VVSMDWKWFF IYPEQGIATV NEIAFPANTP VYFKVTSNSV MNSFFIPRLG SQIYAMAGMQ TRLHLIANEP GTYDGISASY SGPGFSGMKF KAIATPDRAA FDQWVAKAKQ SPNTMSDMAA FEKLAAPSEY NQVEYFSNVK PDLFADVINK FMAHGKSMDM TQPEGEHSAH EGMEGMDMSH AESAH Bacterial inner membrane;Cytoplasm;Periplasmic space 91 Structure PDBTM Structure PDBTM Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA Fusion PhoA Fusion PhoA 3.45 EMBO J. 1992 Sep;11(9):3209-17. J Biol Chem 1990 Aug 5;265(22):12978-86 Biochim Biophys Acta 1990 Jul 25;1018(2-3):124-7 J Biol Chem. 1993 Aug 5;268(22):16781-7. J Mol Biol. 1993 Feb 5;229(3):794-6. Nat Struct Biol 2000 Oct;7(10):910-7 Based on XRAY structure Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Ubiquinol oxidase polypeptide I Escherichia coli P0ABI8 P18401 Q2MBZ5 3.50 XRAY fig 3 MFGKLSLDAV PFHEPIVMVT IAGIILGGLA LVGLITYFGK WTYLWKEWLT SVDHKRLGIM YIIVAIVMLL RGFADAIMMR SQQALASAGE AGFLPPHHYD QIFTAHGVIM IFFVAMPFVI GLMNLVVPLQ IGARDVAFPF LNNLSFWFTV VGVILVNVSL GVGEFAQTGW LAYPPLSGIE YSPGVGVDYW IWSLQLSGIG TTLTGINFFV TILKMRAPGM TMFKMPVFTW ASLCANVLII ASFPILTVTV ALLTLDRYLG THFFTNDMGG NMMMYINLIW AWGHPEVYIL ILPVFGVFSE IAATFSRKRL FGYTSLVWAT VCITVLSFIV WLHHFFTMGA GANVNAFFGI TTMIIAIPTG VKIFNWLFTM YQGRIVFHSA MLWTIGFIVT FSVGGMTGVL LAVPGADFVL HNSLFLIAHF HNVIIGGVVF GCFAGMTYWW PKAFGFKLNE TWGKRAFWFW IIGFFVAFMP LYALGFMGMT RRLSQQIDPQ FHTMLMIAAS GAVLIALGIL CLVIQMYVSI RDRDQNRDLT GDPWGGRTLE WATSSPPPFY NFAVVPHVHE RDAFWEMKEK GEAYKKPDHY EEIHMPKNSG AGIVIAAFST IFGFAMIWHI WWLAIVGFAG MIITWIVKSF DEDVDYYVPV AEIEKLENQH FDEITKAGLK NGN Bacterial inner membrane;Cytoplasm;Periplasmic space 89 Fusion PhoA Structure PDBTM Structure PDBTM Fusion LacZ Structure PDBTM Fusion PhoA Fusion PhoA Fusion PhoA Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Fusion PhoA Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA Fusion PhoA Fusion LacZ Fusion LacZ Fusion PhoA Fusion LacZ Fusion PhoA Fusion PhoA Fusion LacZ Fusion PhoA 0.00 Fusion GFP 0.57 J Biol Chem 1990 Aug 5;265(22):12978-86 Biochim Biophys Acta 1990 Jul 25;1018(2-3):124-7 Nat Struct Biol 2000 Oct;7(10):910-7 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cytochrome O ubiquinol oxidase subunit III Escherichia coli P18402 P0ABJ4 P0ABJ3 Q2MBZ6 P0ABJ5 3.50 XRAY fig 3 MATDTLTHAT AHAHEHGHHD AGGTKIFGFW IYLMSDCILF SILFATYAVL VNGTAGGPTG KDIFELPFVL VETFLLLFSS ITYGMAAIAM YKNNKSQVIS WLALTWLFGA GFIGMEIYEF HHLIVNGMGP DRSGFLSAFF ALVGTHGLHV TSGLIWMAVL MVQIARRGLT STNRTRIMCL SLFWHFLDVV WICVFTVVYL MGAM Bacterial inner membrane;Cytoplasm;Periplasmic space 92 Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA Fusion LacZ Structure PDBTM Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA Structure PDBTM Structure PDBTM Fusion LacZ Structure PDBTM Structure PDBTM Fusion PhoA 1.36 Fusion GFP 0.38 J Biol Chem 1990 Aug 5;265(22):12978-86 Biochim Biophys Acta 1990 Jul 25;1018(2-3):124-7 Nat Struct Biol 2000 Oct;7(10):910-7 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Cytochrome O ubiquinol oxidase protein cyoD Escherichia coli P18403 P77116 P0ABJ7 P0ABJ6 Q2MBZ7 P0ABJ8 MSHSTDHSGA SHGSVKTYMT GFILSIILTV IPFWMVMTGA ASPAVILGTI LAMAVVQVLV HLVCFLHMNT KSDEGWNMTA FVFTVLIIAI LVVGSIWIMW NLNYNMMMH Bacterial inner membrane;Cytoplasm;Periplasmic space 90 Fusion LacZ Fusion PhoA Fusion LacZ Fusion PhoA Fusion PhoA 3.02 Fusion GFP 0.02 Eur J Biochem 1993 Sep 1;216(2):477-85 Biochim Biophys Acta 1990 Jul 25;1018(2-3):124-7 Nat Struct Biol 2000 Oct;7(10):910-7 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Protoheme IX farnesyltransferase Escherichia coli P18404 P77115 P0AEA7 P0AEA6 P0AEA5 Q2MBZ8 MMFKQYLQVT KPGIIFGNLI SVIGGFLLAS KGSIDYPLFI YTLVGVSLVV ASGCVFNNYI DRDIDRKMER TKNRVLVKGL ISPAVSLVYA TLLGIAGFML LWFGANPLAC WLGVMGFVVY VGVYSLYMKR HSVYGTLIGS LSGAAPPVIG YCAVTGEFDS GAAILLAIFS LWQMPHSYAI AIFRFKDYQA ANIPVLPVVK GISVAKNHIT LYIIAFAVAT LMLSLGGYAG YKYLVVAAAV SVWWLGMALR GYKVADDRIW ARKLFGFSII AITALSVMMS VDFMVPDSHT LLAAVW Bacterial inner membrane;Cytoplasm;Periplasmic space 86 Fusion PhoA Fusion LacZ Fusion LacZ Fusion PhoA Fusion LacZ Fusion LacZ Fusion PhoA Fusion PhoA Fusion PhoA 0.90 Fusion GFP 0.03 J Biol Chem 1990 Aug 5;265(22):12978-86 Biochim Biophys Acta 1990 Jul 25;1018(2-3):124-7 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License C4-dicarboxylate transport protein Rhizobium meliloti P20672 MIIEHSAEVR GKTPLYRHLY VQVLAAIAAG ILLGHFYPDI GTELKPLGDA FIRLVKMIIA PVIFLTVATG IAGMTDLAKV GRVAGKAMIY FLAFSTLALV VGLVVANVVQ PGAGMHIDPA SLDAKAVATY AEKAHEQSIT GFLMNIIPTT LVGAFAEGDI LQVLFISVLF GISLAIVGKK AEPVVDFLQA LTLPIFRLVA ILMKAAPIGA FGAMAFTIGK YGIASIANLA MLIGTFYLTS FLFVFIVLGA VARYNGFSIL SLIRYIKEEL LLVLGTSSSE AALPGLMNKM EKAGCKRSVV GLVIPTGYSF NLDGTNIYMT LAALFIAQAT DTPLSYGDQI LLLLVAMLSS KGAAGITGAG FITLAATLSV VPSVPVAGMA LILGIDRFMS ECRALTNFVG NAVATIVVAK WEGELDQAQL SAALGGEASV EAIPAVVQPA E Bacterial inner membrane;Cytoplasm;Periplasmic space 79 Fusion PhoA 475 1100846 136 Fusion PhoA 38 1100846 9 Fusion PhoA 415 1100846 120 Fusion PhoA 439 1100846 120 Fusion PhoA 425 1100846 96 Fusion LacZ 175 M1971 48 Fusion LacZ 2030 M1971 610 Fusion PhoA 320 1100846 120 Fusion LacZ 2650 M1971 585 Fusion LacZ 280 M1971 85 Mol Gen Genet 1993 Oct;241(1-2):106-14 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Anaerobic C4-dicarboxylate transporter dcuA Escherichia coli P04539 P0ABN7 P0ABN6 P0ABN5 Q2M6G6 P0ABN8 MLVVELIIVL LAIFLGARLG GIGIGFAGGL GVLVLAAIGV KPGNIPFDVI SIIMAVIAAI SAMQVAGGLD YLVHQTEKLL RRNPKYITIL APIVTYFLTI FAGTGNISLA TLPVIAEVAK EQGVKPCRPL STAVVSAQIA ITASPISAAV VYMSSVMEGH GISYLHLLSV VIPSTLLAVL VMSFLVTMLF NSKLSDDPIY RKRLEEGLVE LRGEKQIEIK SGAKTSVWLF LLGVVGVVIY AIINSPSMGL VEKPLMNTTN AILIIMLSVA TLTTVICKVD TDNILNSSTF KAGMSACICI LGVAWLGDTF VSNNIDWIKD TAGEVIQGHP WLLAVIFFFA SALLYSQAAT AKALMPMALA LNVSPLTAVA SFAAVSGLFI LPTYPTLVAA VQMDDTGTTR IGKFVFNHPF FIPGTLGVAL AVCFGFVLGS FML Bacterial inner membrane;Cytoplasm;Periplasmic space 73 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 20 Fusion BlaM 105 Fusion BlaM 40 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 15 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 90 Fusion BlaM 85 Fusion BlaM 120 Fusion BlaM 115 Fusion BlaM 10 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 20 Fusion BlaM 45 Fusion BlaM 30 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 20 Fusion BlaM 30 Fusion BlaM 35 Fusion BlaM 25 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 15 Fusion BlaM 85 Fusion BlaM 90 Fusion BlaM 95 Fusion BlaM 85 Fusion BlaM 60 Fusion BlaM 60 Fusion BlaM 45 Fusion BlaM 105 Fusion BlaM 100 Fusion PhoA 0.64 Fusion GFP 0.26 J Bacteriol 1998 Sep;180(18):4821-7 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sensor protein dcuS Escherichia coli P39272 P76795 P0AEC9 P0AEC8 Q2M6H9 N/A NMR The structure of the water-soluble, periplasmic domain of the fumarate sensor DcuS (DcuS-pd) has been determined by NMR spectroscopy in solution. MRHSLPYRML RKRPMKLSTT VILMVSAVLF SVLLVVHLIY FSQISDMTRD GLANKALAVA RTLADSPEIR QGLQKKPQES GIQAIAEAVR KRNDLLFIVV TDMQSLRYSH PEAQRIGQPF KGDDILKALN GEENVAINRG FLAQALRVFT PIYDENHKQI GVVAIGLELS RVTQQINDSR WSIIWSVLFG MLVGLIGTCI LVKVLKKILF GLEPYEISTL FEQRQAMLQS IKEGVVAVDD RGEVTLINDA AQELLNYRKS QDDEKLSTLS HSWSQVVDVS EVLRDGTPRR DEEITIKDRL LLINTVPVRS NGVIIGAIST FRDKTEVRKL MQRLDGLVNY ADALRERSHE FMNKLHVILG LLHLKSYKQL EDYILKTANN YQEEIGSLLG KIKSPVIAGF LISKINRATD LGHTLILNSE SQLPDSGSED QVATLITTLG NLIENALEAL GPEPGGEISV TLHYRHGWLH CEVNDDGPGI APDKIDHIFD KGVSTKGSER GVGLALVKQQ VENLGGSIAV ESEPGIFTQF FVQIPWDGER SNR Bacterial inner membrane;Cytoplasm;Periplasmic space 83 Fusion BlaM 2 Fusion BlaM 100 Structure PDBTM Fusion BlaM 270 Fusion BlaM 250 Fusion BlaM 240 Fusion BlaM 15 Fusion BlaM 15 Fusion BlaM 15 Fusion BlaM 40 Fusion BlaM 30 Fusion BlaM 8 Fusion BlaM 2 Fusion BlaM 2 Fusion BlaM 2 Fusion PhoA 0.00 Fusion GFP 0.80 J Bacteriol 1999 Feb;181(4):1238-48 J Biol Chem. 2003 Oct 3;278(40):39185-8. Epub 2003 Aug 7. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Type 4 prepilin-like proteins leader peptide processing enzyme, OutO, GSPO Pectobacterium carotovorum subsp. carotovorum P31712 MDDLREFAQL FPAWWFGALG VLGLIVGSFL NVVIYRLPIM LERRWRQDIE LETGVADPDT RYNLWWPPSS CPHCQQAIAV KDNIPLFSWL WLRGRSRCCH QSVSVQYPLV EVITMLAFLA AGLLWLPGMA LWGALILLSF LLVLTVIDIK TLLLPDELTL SLLWMGLLFN LSGTFVSLND AVVGAMAGYL SLWLLYWAFK YATGKEALGY GDFKLLAALG AWLGWQALPN LVLVAALSGL VVTLIWRGLR KEDTAKPLAF GPWLAIGGVF GMIMNGFNL Bacterial inner membrane;Cytoplasm;Periplasmic space 69 Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM yes 5 No tm region before fusion point, therefore no start signal Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 80 Fusion BlaM 80 Fusion BlaM 320 Fusion BlaM 160 Fusion BlaM 160 Fusion BlaM 80 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 10 Fusion BlaM 80 Fusion BlaM 80 Fusion BlaM 60 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 20 Fusion BlaM 10 Fusion BlaM 10 Fusion BlaM 40 Fusion BlaM 20 Fusion BlaM 20 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM yes 320 Mol Microbiol 1994 May;12(3):445-57 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Glucose dehydrogenase [pyrroloquinoline-quinone] Escherichia coli P15877 MAINNTGSRR LLVTLTALFA ALCGLYLLIG GGWLVAIGGS WYYPIAGLVM LGVAWMLWRS KRAALWLYAA LLLGTMIWGV WEVGFDFWAL TPRSDILVFF GIWLILPFVW RRLVIPASGA VAALVVALLI SGGILTWAGF NDPQEINGTL SADATPAEAI SPVADQDWPA YGRNQEGQRF SPLKQINADN VHNLKEAWVF RTGDVKQPND PGEITNEVTP IKVGDTLYLC TAHQRLFALD AASGKEKWHY DPELKTNESF QHVTCRGVSY HEAKAETASP EVMADCPRRI ILPVNDGRLI AINAENGKLC ETFANKGVLN LQSNMPDTKP GLYEPTSPPI ITDKTIVMAG SVTDNFSTRE TSGVIRGFDV NTGELLWAFD PGAKDPNAIP SDEHTFTFNS PNSWAPAAYD AKLDLVYLPM GVTTPDIWGG NRTPEQERYA SSILALNATT GKLAWSYQTV HHDLWDMDLP AQPTLADITV NGQKVPVIYA PAKTGNIFVL DRRNGELVVP APEKPVPQGA AKGDYVTPTQ PFSELSFRPT KDLSGADMWG ATMFDQLVCR VMFHQMRYEG IFTPPSEQGT LVFPGNLGMF EWGGISVDPN REVAIANPMA LPFVSKLIPR GPGNPMEQPK DAKGTGTESG IQPQYGVPYG VTLNPFLSPF GLPCKQPAWG YISALDLKTN EVVWKKRIGT PQDSMPFPMP VPVPFNMGMP MLGGPISTAG NVLFIAATAD NYLRAYNMSN GEKLWQGRLP AGGQATPMTY EVNGKQYVVI SAGGHGSFGT KMGDYIVAYA LPDDVK Bacterial inner membrane;Cytoplasm;Periplasmic space 85 Fusion PhoA 0.02 Fusion LacZ 26 Fusion PhoA 70 Fusion LacZ 0.10 Fusion PhoA 0.01 Fusion LacZ 2.6 Fusion PhoA 50 Fusion LacZ 0.13 Fusion PhoA 0.02 Fusion LacZ 2.0 Fusion PhoA 60 Fusion LacZ 0.19 J Biol Chem 1993 Jun 15;268(17):12812-7 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Anaerobic dimethyl sulfoxide reductase chain C Escherichia coli P18777 MGSGWHEWPL MIFTVFGQCV AGGFIVLALA LLKGDLRAEA QQRVIACMFG LWVLMGIGFI ASMLHLGSPM RAFNSLNRVG ASALSNEIAS GSIFFAVGGI GWLLAMLKKL SPALRTLWLI VTMVLGVIFV WMMVRVYNSI DTVPTWYSIW TPMGFFLTMF MGGPLLGYLL LSLAGVDGWA MRLLPAISVL ALVVSGVVSV MQGAELATIH SSVQQAAALV PDYGALMSWR IVLLAVALCL WIAPQLKGYQ PAVPLLSVSF ILLLAGELIG RGVFYGLHMT VGMAVAS Bacterial inner membrane;Cytoplasm;Periplasmic space 85 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 320 Fusion PhoA 350 1100846 Fusion BlaM 1280 Fusion BlaM 1280 Fusion BlaM 1280 Fusion BlaM 320 Fusion BlaM 80 Fusion BlaM 160 Fusion BlaM 0 Fusion BlaM 0 Fusion BlaM 0 Fusion PhoA 350 1100846 Fusion BlaM 1280 Fusion BlaM 1280 Fusion BlaM 160 Fusion BlaM 80 Fusion BlaM 0 Fusion BlaM 640 Fusion PhoA 350 1100846 Fusion PhoA 2.42 Fusion GFP 0.06 J Bacteriol 1990 Oct;172(10):5938-48 No numerical data about topology J Biol Chem. 1993 Feb 15;268(5):3238-44. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Disulfide bond formation protein B Escherichia coli P0A6M2 P30018 Q47408 3.70 XRAY fig 1 N/A NMR by similarity N/A NMR by similarity N/A NMR by similarity N/A NMR by similarity N/A NMR by similarity 3.70 XRAY According to 19214188/Fig1 3.30 XRAY According to 19214188/Fig1 3.70 XRAY According to 18775700/Fig1 MLRFLNQCSQ GRGAWLLMAF TALALELTAL WFQHVMLLKP CVLCIYERCA LFGVLGAALI GAIAPKTPLR YVAMVIWLYS AFRGVQLTYE HTMLQLYPSP FATCDFMVRF PEWLPLDKWV PQVFVASGDC AERQWDFLGL EMPQWLLGIF IAYLIVAVLV VISQPFKAKK RDLFGR Bacterial inner membrane;Cytoplasm;Periplasmic space 90 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 0.32 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 15 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 20 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 41 7957076 Fusion PhoA 31 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 2.3 7957076 Structure PDBTM Fusion PhoA 2.8 7957076 Structure PDBTM Structure PDBTM Fusion PhoA 3.0 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 1.6 7957076 Fusion PhoA 17 7957076 Fusion PhoA 20 7957076 Fusion PhoA 17 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 27 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 39 7957076 Fusion PhoA 11 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 8.9 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 9.6 7957076 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 1.0 7957076 Fusion PhoA 0.91 7957076 Fusion PhoA 0.00 Fusion GFP 1.24 EMBO J 1994 Nov 1;13(21):5121-7 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Cell. 2006 Nov 17;127(4):789-801. FEBS Lett. 2008 Oct 15;582(23-24):3301-7. doi: 10.1016/j.febslet.2008.07.063. Mol Cell. 2008 Sep 26;31(6):896-908. doi: 10.1016/j.molcel.2008.08.028. EMBO J. 2009 Mar 18;28(6):779-91. doi: 10.1038/emboj.2009.21. Epub 2009 Feb 12. Proteins. 2011 May;79(5):1365-75. doi: 10.1002/prot.22877. Epub 2011 Feb 18. J Biomol NMR. 2011 Nov;51(3):227-33. doi: 10.1007/s10858-011-9565-6. Epub 2011 J Mol Biol. 2013 May 27;425(10):1670-82. doi: 10.1016/j.jmb.2013.02.009. Epub Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Thiol:disulfide interchange protein dsbD precursor Escherichia coli P36655 P76796 Q2M6G8 1.90 XRAY periplasmic N-terminal domain 2.30 XRAY periplasmic N-terminal domain DsbDalpha/DsbC complex 1.65 XRAY periplasmic N-terminal domain DsbDalpha/DsbC complex 2.85 XRAY DsbD contains two periplasmically oriented domains at the N- and C-terminus 1.94 XRAY DsbD consists of an N-terminal periplasmic domain (nDsbD), a C-terminal periplasmic domain, and a central transmembrane domain. 1.65 XRAY DsbD is composed of an N-terminal (nDsbD) and a C-terminal (cDsbD) periplasmic domain, connected by a central transmembrane domain. 1.30 XRAY DsbD is composed of an N-terminal (nDsbD) and a C-terminal (cDsbD) periplasmic domain, connected by a central transmembrane domain. 1.10 XRAY DsbD is composed of an N-terminal (nDsbD) and a C-terminal (cDsbD) periplasmic domain, connected by a central transmembrane domain. 0.99 XRAY DsbD is composed of an N-terminal (nDsbD) and a C-terminal (cDsbD) periplasmic domain, connected by a central transmembrane domain. MAQRIFTLIL LLCSTSVFAG LFDAPGRSQF VPADQAFAFD FQQNQHDLNL TWQIKDGYYL YRKQIRITPE HAKIADVQLP QGVWHEDEFY GKSEIYRDRL TLPVTINQAS AGATLTVTYQ GCADAGFCYP PETKTVPLSE VVANNAAPQP VSVPQQEQPT AQLPFSALWA LLIGIGIAFT PCVLPMYPLI SGIVLGGKQR LSTARALLLT FIYVQGMALT YTALGLVVAA AGLQFQAALQ HPYVLIGLAI VFTLLAMSMF GLFTLQLPSS LQTRLTLMSN RQQGGSPGGV FVMGAIAGLI CSPCTTAPLS AILLYIAQSG NMWLGGGTLY LYALGMGLPL MLITVFGNRL LPKSGPWMEQ VKTAFGFVIL ALPVFLLERV IGDVWGLRLW SALGVAFFGW AFITSLQAKR GWMRIVQIIL LAAALVSVRP LQDWAFGATH TAQTQTHLNF TQIKTVDELN QALVEAKGKP VMLDLYADWC VACKEFEKYT FSDPQVQKAL ADTVLLQANV TANDAQDVAL LKHLNVLGLP TILFFDGQGQ EHPQARVTGF MDAETFSAHL RDRQP Bacterial inner membrane;Cytoplasm;Periplasmic space 90 Fusion PhoA Fusion LacZ 140.8 M1971 Fusion PhoA less than 0.1 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 98 8419303 Structure PDBTM Structure PDBTM Fusion LacZ 3.1 M1971 Fusion PhoA 17.0 1100846 Fusion PhoA 45 8419303 Fusion LacZ less than 0.5 M1971 Fusion PhoA 25.2 1100846 Fusion PhoA 100 8419303 Fusion LacZ less than 0.5 M1971 Fusion PhoA 25.0 1100846 Fusion PhoA 87 8419303 Fusion PhoA 48 8419303 Fusion PhoA 62 8419303 Fusion LacZ less than 0.5 M1971 Fusion PhoA 70.4 1100846 Fusion PhoA 0.7 8419303 Fusion PhoA 0 8419303 Fusion LacZ 35.1 M1971 Fusion PhoA 3.5 1100846 Fusion PhoA 8 8419303 Fusion LacZ 111.8 M1971 Fusion PhoA 1.9 1100846 Fusion PhoA 33 8419303 Fusion LacZ 1.1 M1971 Fusion PhoA 29.1 1100846 Fusion PhoA 57 8419303 Fusion LacZ 1.5 M1971 Fusion PhoA 31.4 1100846 Fusion PhoA 52 8419303 Fusion PhoA 0 8419303 Fusion LacZ 25.8 M1971 Fusion PhoA 5.9 1100846 Fusion PhoA 1 8419303 Fusion LacZ 79.1 M1971 Fusion PhoA 0.5 1100846 Fusion PhoA 66 8419303 Fusion PhoA 100 8419303 Fusion PhoA 45 8419303 Fusion LacZ 1.4 M1971 Fusion PhoA 21.7 1100846 Fusion LacZ 0.7 M1971 Fusion PhoA 34.7 1100846 Fusion LacZ 42.6 M1971 Fusion PhoA 2.2 1100846 Fusion PhoA 3 8419303 Fusion LacZ 19.2 M1971 Fusion PhoA 0.9 1100846 Fusion PhoA 0 8419303 Fusion LacZ 6.9 M1971 Fusion PhoA 12.7 1100846 Fusion PhoA 53 8419303 Fusion LacZ 4.9 M1971 Fusion PhoA 12.5 1100846 Fusion PhoA 43 8419303 Fusion PhoA 0 8419303 Fusion LacZ 44.4 M1971 Fusion PhoA 1.3 1100846 Fusion PhoA 0 8419303 Fusion PhoA 0 8419303 Fusion LacZ 33.1 M1971 Fusion PhoA 1.0 1100846 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion LacZ 1.1 M1971 Fusion PhoA 31.6 1100846 Fusion LacZ 1.2 M1971 Fusion PhoA 31.2 1100846 Fusion PhoA 87 8419303 Fusion PhoA 89 8419303 Fusion LacZ less than 0.5 M1971 Fusion PhoA 16.8 1100846 Fusion PhoA 75 8419303 Fusion PhoA 96 8419303 Fusion PhoA 0.45 Fusion GFP 0.00 Structure PDBTM EMBO J 1999 Nov 1;18(21):5963-71 Mol Microbiol 2000 Mar;35(5):1099-109 No numerical data Mol Microbiol 2000 Mar;35(6):1360-74 Biochemistry. 2002 Jun 4;41(22):6920-7. EMBO J. 2002 Sep 16;21(18):4774-84. EMBO J. 2004 Apr 21;23(8):1709-19. Epub 2004 Apr 1. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Structure. 2005 Jul;13(7):985-93. J Mol Biol. 2006 May 5;358(3):829-45. Epub 2006 Feb 28. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Di-/tripeptide transporter Lactococcus lactis subsp. lactis P36574 Q9CHM6 P0C2U2 P0C2U3 MQNLNKTEKT FFGQPRGLLT LFQTEFWERF SYYGMRAILV YYLYALTTAD NAGLGLPKAQ AMAIVSIYGA LVYLSTIVGG WVADRLLGAS RTIFLGGILI TLGHIALATP FGLSSLFVAL FLIILGTGML KPNISNMVGH LYSKDDSRRD TGFNIFVVGI NMGSLIAPLI VGTVGQGVNY HLGFSLAAIG MIFALFAYWY GRLRHFPEIG REPSNPMDSK ARRNFLITLT IVVIVAIIGF FLLYQASPAN FINNFINVLS IIGIVVPIIY FVMMFTSKKV ESDERRKLTA YIPLFLSAIV FWAIEEQSST IIAVWGESRS NLDPTWFGIT FHIDPSWYQL LNPLFIVLLS PIFVRLWNKL GERQPSTIVK FGLGLMLTGI SYLIMTLPGL LNGTSGRASA LWLVLMFAVQ MAGELLVSPV GLSVSTKLAP VAFQSQMMAM WFLADSTSQA INAQITPLFK AATEVHFFAI TGIIGIIVGI ILLIVKKPIL KLMGDVR Bacterial inner membrane;Cytoplasm;Periplasmic space 91 Fusion PhoA 127 1100846 Fusion PhoA 135 1100846 Fusion PhoA 152 1100846 Fusion PhoA 287 1100846 Fusion PhoA 473 1100846 Fusion PhoA 400 1100846 Fusion PhoA 18 1100846 Fusion PhoA 614 1100846 Fusion PhoA 306 1100846 Fusion PhoA 60 1100846 Fusion PhoA 7 1100846 Fusion PhoA 12 1100846 Fusion PhoA 353 1100846 Fusion PhoA 577 1100846 Fusion PhoA 550 1100846 Fusion PhoA 404 1100846 Fusion PhoA 12 1100846 Fusion PhoA 386 1100846 Fusion PhoA 211 1100846 Fusion PhoA 14 1100846 Fusion PhoA 210 1100846 Fusion PhoA 188 1100846 Fusion PhoA 19 1100846 Fusion PhoA 4 1100846 Fusion PhoA 48 1100846 Fusion PhoA 278 1100846 Fusion PhoA 626 1100846 Fusion PhoA 459 1100846 Fusion PhoA 823 1100846 Fusion PhoA 343 1100846 Fusion PhoA 125 1100846 Fusion PhoA 806 1100846 Fusion PhoA 300 1100846 Fusion PhoA 267 1100846 Fusion PhoA 3 1100846 Fusion PhoA 16 1100846 Fusion PhoA 98 1100846 Chemical_modification Cys yes 98 Fusion PhoA 163 1100846 Fusion PhoA 242 1100846 Fusion PhoA 71 1100846 Chemical_modification Cys yes 71 Fusion PhoA 32 1100846 Chemical_modification Cys yes 32 Fusion PhoA 4 1100846 Chemical_modification Cys yes 4 Biochemistry 1997 Jun 3;36(22):6777-85 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Osmolarity sensor protein envZ Escherichia coli P02933 P0AEJ4 Q2M769 P0AEJ5 N/A NMR histidine kinase domain N/A NMR histidine kinase domain N/A MODEL histidine kinase domain MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT EVRVEVNKSS PVVWLKTWLS PNIWVRVPLT EIHQGDFSPL FRYTLAIMLL AIGGAWLFIR IQNRPLVDLE HAALQVGKGI IPPPLREYGA SEVRSVTRAF NHMAAGVKQL ADDRTLLMAG VSHDLRTPLT RIRLATEMMS EQDGYLAESI NKDIEECNAI IEQFIDYLRT GQEMPMEMAD LNAVLGEVIA AESGYEREIE TALYPGSIEV KMHPLSIKRA VANMVVNAAR YGNGWIKVSS GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF VRGDSARTIS GTGLGLAIVQ RIVDNHNGML ELGTSERGGL SIRAWLPVPV TRAQGTTKEG Bacterial inner membrane;Cytoplasm;Periplasmic space 88 Fusion BlaM Protease Partial Proteolysis (ProtK protease) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM Fusion PhoA 0.01 Fusion GFP 0.40 J Biol Chem 1987 Dec 5;262(34):16433-8 Nature. 1998 Nov 5;396(6706):88-92. Nat Struct Biol. 1999 Aug;6(8):729-34. J Mol Biol. 2003 Apr 25;328(2):409-18. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Biopolymer transport exbB protein Escherichia coli P18783 P0ABU8 P0ABU7 Q2M9J2 MGNNLMQTDL SVWGMYQHAD IVVKCVMIGL ILASVVTWAI FFSKSVEFFN QKRRLKREQQ LLAEARSLNQ ANDIAADFGS KSLSLHLLNE AQNELELSEG SDDNEGIKER TSFRLERRVA AVGRQMGRGN GYLATIGAIS PFVGLFGTVW GIMNSFIGIA QTQTTNLAVV APGIAEALLA TAIGLVAAIP AVVIYNVFAR QIGGFKAMLG DVAAQVLLLQ SRDLDLEASA AAHPVRVAQK LRAG Bacterial inner membrane;Cytoplasm;Periplasmic space 82 Protease Partial Proteolysis (AmpK protease) Fusion BlaM yes 4 There is no signal to process the Bla gene to the periplasm, therefore this results has no evidence about the topology Fusion BlaM yes 4 There is no signal to process the Bla gene to the periplasm, therefore this results has no evidence about the topology Fusion BlaM yes 4 There is no signal to process the Bla gene to the periplasm, therefore this results has no evidence about the topology Fusion BlaM yes 4 Probably inverted topology, because only one TM segment is included, and no signal to the correct topology Fusion BlaM yes 4 Probably inverted topology, because only one TM segment is included, and no signal to the correct topology Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Protease Partial Proteolysis (ProtK protease) Fusion BlaM Fusion BlaM Fusion BlaM Fusion PhoA 0.00 Fusion GFP 1.07 J Biol Chem 1993 Mar 15;268(8):6050-7 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Formate dehydrogenase, cytochrome B556(FDO) subunit Escherichia coli P32174 P0AEL2 P0AEL1 P0AEL0 Q2M8I9 MKRRDTIVRY TAPERINHWI TAFCFILAAV SGLGFLFPSF NWLMQIMGTP QLARILHPFV GVVMFASFII MFFRYWHHNL INRDDIFWAK NIRKIVVNEE VGDTGRYNFG QKCVFWAAII FLVLLLVSGV IIWRPYFAPA FSIPVIRFAL MLHSFAAVAL IVVIMVHIYA ALWVKGTITA MVEGWVTSAW AKKHHPRWYR EVRKTTEKKA E Bacterial inner membrane;Cytoplasm;Periplasmic space 99 Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion BlaM Fusion PhoA 0.00 Fusion GFP 2.12 J Bacteriol 1998 Dec;180(24):6625-34 Science. 2005 May 27;308(5726):1321-3. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sensor protein fixL Rhizobium meliloti P10955 1.40 XRAY sensor histidine kinase 1.40 XRAY sensor histidine kinase MLSKSGIERT QWGRRVVRWR GDGVAAYIVA AIVTSSVLAI RMIRAEPIGE GLLLFSFIPA ILVVALIGGR NPILFAAGLS LVAAVSHQQI SSADGPSVVE LLVFGSAVLL IVALGEVLEA ARRAIDRTED VVRARDAHLR SILDTVPDAT VVSATDGTIV SFNAAAVRQF GYAEEEVIGQ NLRILMPEPY RHEHDGYLQR YMATGEKRII GIDRVVSGQR KDGSTFPMKL AVGEMRSGGE RFFTGFIRDL TEREESAARL EQIQAELARL ARLNEMGEMA STLAHELNQP LSAIANYSHG CTRLLRDMDD AVATRIREAL EEVASQSLRA GQIIKHLREF VTKGETEKAP EDIRKLVEES AALALVGSRE QGVRTVFEYL PGAEMVLVDR IQVQQVLINL MRNAIEAMRH VDRRELTIRT MPADPGEVAV VVEDTGGGIP EEVAGQLFKP FVTTKASGMG IGLSISKRIV EAHGGEMTVS KNEAGGATFR FTLPAYLDER IVAND Bacterial inner membrane;Cytoplasm;Periplasmic space 88 Fusion PhoA 27 1100846 Fusion PhoA 35 1100846 Fusion PhoA 25 1100846 Fusion PhoA 29 1100846 Fusion PhoA 31 1100846 Structure PDBTM Structure PDBTM Fusion PhoA 2 1100846 Fusion PhoA 0.8 1100846 J Bacteriol 1993 Feb;175(4):1103-9 Acta Crystallogr D Biol Crystallogr. 1999 Jun;55(Pt 6):1215-8. J Biol Chem. 1999 Aug 13;274(33):23176-84. J Mol Biol. 2000 Aug 11;301(2):415-31. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Folate transporter 1, RFC Homo sapiens P41440 Q13026 O60227 O00553 B2R7U8 B7Z8C3 E9PFY4 Q9BTX8 MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q Plasma membrane;Cytoplasm;Extracellular 85 Immunolocalisation Epitope Insertion yes Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) PostTransMod NGlyc Immunolocalisation Epitope Insertion yes Immunolocalisation Epitope Insertion (HAEI epitope) Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) Immunolocalisation Epitope Insertion yes Immunolocalisation Epitope Insertion (HAEI epitope) Immunolocalisation Epitope Insertion yes Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) Chemical_modification Cys yes Chemical_modification Cys yes Immunolocalisation Epitope Insertion yes Chemical_modification Cys yes Immunolocalisation Epitope Insertion (HAEI epitope) Chemical_modification Cys yes Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) Chemical_modification Cys yes Immunolocalisation Epitope Insertion yes 0.8 (HAEI epitope) Immunolocalisation Epitope Insertion yes J Biol Chem 1999 Jun 4;274(23):16269-78 Biochim Biophys Acta. 2002 Aug 31;1564(2):333-42. Biochem J. 2004 Feb 15;378(Pt 1):201-6. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Frizzled protein precursor Drosophila melanogaster P18537 Q9VUE0 Q9VUE2 MWRQILFILP TLIQGVQRYD QSPLDASPYY RSGGGLMASS GTELDGLPHH NRCEPITISI CKNIPYNMTI MPNLIGHTKQ EEAGLEVHQF APLVKIGCSD DLQLFLCSLY VPVCTILERP IPPCRSLCES ARVCEKLMKT YNFNWPENLE CSKFPVHGGE DLCVAENTTS SASTAATPTR SVAKVTTRKH QTGVESPHRN IGFVCPVQLK TPLGMGYELK VGGKDLHDCG APCHAMFFPE RERTVLRYWV GSWAAVCVAS CLFTVLTFLI DSSRFRYPER AIVFLAVCYL VVGCAYVAGL GAGDSVSCRE PFPPPVKLGR LQMMSTITQG HRQTTSCTVL FMALYFCCMA AFAWWSCLAF AWFLAAGLKW GHEAIENKSH LFHLVAWAVP ALQTISVLAL AKVEGDILSG VCFVGQLDTH SLGAFLILPL CIYLSIGALF LLAGFISLFR IRTVMKTDGK RTDKLERLML RIGFFSGLFI LPAVGLLGCL FYEYYNFDEW MIQWHRDICK PFSIPCPAAR APGSPEARPI FQIFMVKYLC SMLVGVTSSV WLYSSKTMVS WRNFVERLQG KEPRTRAQAY V Plasma membrane;Cytoplasm;Extracellular 94 Fusion Suc2 Fusion Suc2 Fusion Suc2 Fusion Suc2 Fusion Suc2 Fusion Suc2 Fusion Suc2 Fusion Suc2 DNA Cell Biol 1999 May;18(5):429-34 No numerical data Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Acetylcholine receptor protein, delta chain precursor Mus musculus P02716 Q61267 MAGPVLTLGL LAALVVCALP GSWGLNEEQR LIQHLFNEKG YDKDLRPVAR KEDKVDVALS LTLSNLISLK EVEETLTTNV WIDHAWVDSR LQWDANDFGN ITVLRLPPDM VWLPEIVLEN NNDGSFQISY ACNVLVYDSG YVTWLPPAIF RSSCPISVTY FPFDWQNCSL KFSSLKYTAK EITLSLKQEE ENNRSYPIEW IIIDPEGFTE NGEWEIVHRA AKLNVDPSVP MDSTNHQDVT FYLIIRRKPL FYIINILVPC VLISFMINLV FYLPGDCGEK TSVAISVLLA QSVFLLLISK RLPATSMAIP LVGKFLLFGM VLVTMVVVIC VIVLNIHFRT PSTHVLSEGV KKFFLETLPK LLHMSRPAEE DPGPRALIRR SSSLGYICKA EEYFSLKSRS DLMFEKQSER HGLARRLTTA RRPPASSEQV QQELFNEMKP AVDGANFIVN HMRDQNSYNE EKDNWNQVAR TVDRLCLFVV TPVMVVGTAW IFLQGVYNQP PLQPFPGDPF SYSEQDKRFI Plasma membrane;Cytoplasm;Extracellular 88 Fusion PL Fusion PL Fusion PL Fusion PL J Cell Biol 1992 Jan;116(2):385-93 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License L-fucose permease Escherichia coli P11551 Q2MA33 3.20 XRAY by similarity 3.14 XRAY by similarity MGNTSIQTQS YRAVDKDAGQ SRSYIIPFAL LCSLFFLWAV ANNLNDILLP QFQQAFTLTN FQAGLIQSAF YFGYFIIPIP AGILMKKLSY KAGIITGLFL YALGAALFWP AAEIMNYTLF LVGLFIIAAG LGCLETAANP FVTVLGPESS GHFRLNLAQT FNSFGAIIAV VFGQSLILSN VPHQSQDVLD KMSPEQLSAY KHSLVLSVQT PYMIIVAIVL LVALLIMLTK FPALQSDNHS DAKQGSFSAS LSRLARIRHW RWAVLAQFCY VGAQTACWSY LIRYAVEEIP GMTAGFAANY LTGTMVCFFI GRFTGTWLIS RFAPHKVLAA YALIAMALCL ISAFAGGHVG LIALTLCSAF MSIQYPTIFS LGIKNLGQDT KYGSSFIVMT IIGGGIVTPV MGFVSDAAGN IPTAELIPAL CFAVIFIFAR FRSQTATN Bacterial inner membrane;Cytoplasm;Periplasmic space 95 Fusion BlaM 2 Fusion BlaM 2 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 2 Structure PDBTM Structure PDBTM Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Structure PDBTM Structure PDBTM Fusion BlaM 50 Structure PDBTM Fusion BlaM 10 Fusion BlaM 4 Structure PDBTM Structure PDBTM Fusion BlaM 2 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 4 Fusion BlaM 50 Structure PDBTM Structure PDBTM Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 20 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 7.5 Fusion BlaM 50 Fusion BlaM 20 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Structure PDBTM Structure PDBTM Fusion BlaM 15 Fusion BlaM 10 Fusion BlaM 7.5 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 2 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 2 Fusion BlaM 2 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 7.5 Fusion BlaM 20 Structure PDBTM Structure PDBTM Fusion BlaM 30 Fusion BlaM 20 Fusion BlaM 20 Fusion BlaM 40 Structure PDBTM Structure PDBTM Fusion BlaM 20 Fusion BlaM 20 Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 2 Structure PDBTM Fusion BlaM 40 Structure PDBTM Structure PDBTM Fusion BlaM 50 Structure PDBTM Structure PDBTM Fusion BlaM 12.5 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 2 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion BlaM 2 Fusion BlaM 2 Fusion BlaM 3 Fusion BlaM 3 Structure PDBTM Structure PDBTM Fusion BlaM 3 Fusion BlaM 50 Fusion BlaM 50 Fusion BlaM 50 Structure PDBTM Structure PDBTM Fusion BlaM 15 Fusion BlaM 10 Fusion BlaM 3 Structure PDBTM Structure PDBTM Fusion BlaM 2 Fusion PhoA 0.00 Fusion GFP 1.01 Mol Microbiol 1995 Feb;15(4):771-83 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Colibri gene id: FucP Nature. 2010 Oct 7;467(7316):734-8. doi: 10.1038/nature09406. Epub 2010 Sep 26. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Histidine transport system permease protein, HisM Salmonella typhimurium P02912 P0A2I8 P0A2I7 MIEIIQEYWK SLLWTDGYRF TGVAITLWLL ISSVVMGGLL AVILAVGRVS SNKFIRFPIW LFTYIFRGTP LYVQLLVFYS GMYTLEIVKG TDLLNAFFRS GLNCTVLALT LNTCAYTTEI FAGAIRSVPH GEIEAARAYG FSSFKMYRCI ILPSALRIAL PAYSNEVILM LHSTALAFTA TVPDLLKIAR DINSATYQPF TAFGIAAVLY LLISYVLISL FRRAERRWLQ HVSSK Bacterial inner membrane;Cytoplasm;Periplasmic space 75 Protease Partial Proteolysis (AmpM protease) Fusion PhoA 6 2594779 Fusion PhoA 33 2594779 Fusion PhoA 34 2594779 Fusion PhoA 9 2594779 Fusion PhoA 15 2594779 Fusion PhoA 26 2594779 Fusion PhoA 1.5 2594779 Protease Partial Proteolysis (CarbA protease) J Biol Chem 1992 Feb 5;267(4):2329-36 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Histidine transport system permease protein, HisQ Salmonella typhimurium P02913 P0A2J0 P0A2I9 MLYGFSGVIL QGAIVTLELA LSSVVLAVLI GLVGAGAKLS QNRVTGLIFE GYTTLIRGVP DLVLMLLIFY GLQIALNVVT DSLGIDQIDI DPMVAGIITL GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTHGQTFRR IMFPAMMRYA LPGIGNNWQV ILKATALVSL LGLEDVVKAT QLAGKSTWEP FYFAVVCGLI YLVFTTVSNG VLLLLERRYS VGVKRADL Bacterial inner membrane;Cytoplasm;Periplasmic space 79 Fusion PhoA yes 14 2594779 Probably inverted topology, the correct Loc is cyto; Fusion PhoA 47 2594779 Fusion PhoA 48 2594779 Fusion PhoA 0.7 2594779 Fusion PhoA 24 2594779 Fusion PhoA 51 2594779 Fusion PhoA 0.3 2594779 Protease Partial Proteolysis (ProtK protease) Protease Partial Proteolysis (CarbA protease) J Biol Chem 1992 Feb 5;267(4):2329-36 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sodium/hydrogen exchanger 1, NHE-1, APNH Homo sapiens P19634 B1ALD6 D3DPL4 Q96EM2 2.70 XRAY Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.(16710297) N/A NMR Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 (17050540) N/A NMR according to fig 1 (16861220) N/A NMR According to 18508767/Fig1 N/A NMR According to 19176522/(Residue Ile337 of NhaA, equivalent to residue Leu457 in NHE1, does not appear to be accessible from the pore and points toward the cytoplasmic side.) MVLRSGICGL SPHRIFPSLL VVVALVGLLP VLRSHGLQLS PTASTIRSSE PPRERSIGDV TTAPPEVTPE SRPVNHSVTD HGMKPRKAFP VLGIDYTHVR TPFEISLWIL LACLMKIGFH VIPTISSIVP ESCLLIVVGL LVGGLIKGVG ETPPFLQSDV FFLFLLPPII LDAGYFLPLR QFTENLGTIL IFAVVGTLWN AFFLGGLMYA VCLVGGEQIN NIGLLDNLLF GSIISAVDPV AVLAVFEEIH INELLHILVF GESLLNDAVT VVLYHLFEEF ANYEHVGIVD IFLGFLSFFV VALGGVLVGV VYGVIAAFTS RFTSHIRVIE PLFVFLYSYM AYLSAELFHL SGIMALIASG VVMRPYVEAN ISHKSHTTIK YFLKMWSSVS ETLIFIFLGV STVAGSHHWN WTFVISTLLF CLIARVLGVL GLTWFINKFR IVKLTPKDQF IIAYGGLRGA IAFSLGYLLD KKHFPMCDLF LTAIITVIFF TVFVQGMTIR PLVDLLAVKK KQETKRSINE EIHTQFLDHL LTGIEDICGH YGHHHWKDKL NRFNKKYVKK CLIAGERSKE PQLIAFYHKM EMKQAIELVE SGGMGKIPSA VSTVSMQNIH PKSLPSERIL PALSKDKEEE IRKILRNNLQ KTRQRLRSYN RHTLVADPYE EAWNQMLLRR QKARQLEQKI NNYLTVPAHK LDSPTMSRAR IGSDPLAYEP KEDLPVITID PASPQSPESV DLVNEELKGK VLGLSRDPAK VAEEDEDDDG GIMMRSKETS SPGTDDVFTP APSDSPSSQR IQRCLSDPGP HPEPGEGEPF FPKGQ Plasma membrane;Cytoplasm;Extracellular 78 Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes PostTransMod NGlyc yes 0.3 PostTransMod NGlyc PostTransMod NGlyc yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Structure PDBTM Chemical_modification Cys yes Structure PDBTM Structure PDBTM Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Structure PDBTM Structure PDBTM Chemical_modification Cys yes Structure PDBTM Chemical_modification Cys yes Chemical_modification Cys yes PostTransMod NGlyc yes yes 0.3 No glycosylation was found Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes PostTransMod NGlyc yes yes 0.3 No glycosylation was found Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Structure PDBTM Structure PDBTM Chemical_modification Cys yes Structure PDBTM Chemical_modification Cys yes Chemical_modification Cys yes Chemical_modification Cys yes Structure PDBTM Structure PDBTM Biochemistry 1994 Aug 30;33(34):10463-9 J Biol Chem. 2000 Mar 17;275(11):7942-9. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. EMBO J. 2006 Jun 7;25(11):2315-25. Epub 2006 May 18. J Biol Chem. 2006 Oct 6;281(40):29817-29. Epub 2006 Jul 21. J Biol Chem. 2007 Jan 26;282(4):2741-51. Epub 2006 Oct 18. J Biol Chem. 2008 Aug 8;283(32):22018-30. doi: 10.1074/jbc.M803447200. Epub 2008 J Biol Chem. 2009 Apr 24;284(17):11546-56. doi: 10.1074/jbc.M809201200. Epub 2009 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Hemolysin secretion ATP-binding protein, HlyB Escherichia coli P08716 2.60 XRAY ABC domain 2.50 XRAY ABC domain 1.60 XRAY ABC domain 1.70 XRAY ABC domain 1.90 XRAY ABC domain 2.60 XRAY ABC domain 2.70 XRAY ABC domain MDSCHKIDYG LYALEILAQY HNVSVNPEEI KHRFDTDGTG LGLTSWLLAA KSLELKVKQV KKTIDRLNFI FLPALVWRED GRHFILTKIS KEVNRYLIFD LEQRNPRVLE QSEFEALYQG HIILITSRSS VTGKLAKFDF TWFIPAIIKY RRIFIETLVV SVFLQLFALI TPLFFQVVMD KVLVHRGFST LNVITVALSV VVVFEIILSG LRTYIFAHST SRIDVELGAK LFRHLLALPI SYFESRRVGD TVARVRELDQ IRNFLTGQAL TSVLDLLFSL IFFAVMWYYS PKLTLVILFS LPCYAAWSVF ISPILRRRLD DKFSRNADNQ SFLVESVTAI NTIKAMAVSP QMTNIWDKQL AGYVAAGFKV TVLATIGQQG IQLIQKTVMI INLWLGAHLV ISGDLSIGQL IAFNMLAGQI VAPVIRLAQI WQDFQQVGIS VTRLGDVLNS PTESYHGKLT LPEINGDITF RNIRFRYKPD SPVILDNINL SIKQGEVIGI VGRSGSGKST LTKLIQRFYI PENGQVLIDG HDLALADPNW LRRQVGVVLQ DNVLLNRSII DNISLANPGM SVEKVIYAAK LAGAHDFISE LREGYNTIVG EQGAGLSGGQ RQRIAIARAL VNNPKILIFD EATSALDYES EHVIMRNMHK ICKGRTVIII AHRLSTVKNA DRIIVMEKGK IVEQGKHKEL LSEPESLYSY LYQLQSD Bacterial inner membrane;Cytoplasm;Periplasmic space 95 Fusion BlaM 5 Fusion BlaM 5 Fusion LacZ 177 M1971 Fusion BlaM 25 Fusion BlaM 25 Fusion BlaM 25 Fusion PhoA 3.7 1100846 Fusion LacZ 171 M1971 Fusion PhoA 3.8 1100846 Fusion LacZ 179 M1971 Fusion PhoA 11.25 1100846 Fusion BlaM 25 Fusion PhoA 28.9 1100846 Fusion PhoA 5.1 1100846 Fusion BlaM 5 Fusion BlaM 25 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 25 Fusion PhoA 33.7 1100846 Fusion BlaM 25 Fusion BlaM 25 Fusion BlaM 25 Fusion LacZ 152 M1971 Fusion LacZ 315 M1971 Fusion BlaM 25 Fusion PhoA 34.8 1100846 Fusion BlaM 25 Fusion BlaM 25 Fusion BlaM 5 Fusion BlaM 5 Fusion LacZ 315 M1971 Fusion BlaM 5 Fusion BlaM 25 Fusion BlaM 25 Fusion LacZ 124 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other SeqMotif Walker A Fusion LacZ 387 M1971 Fusion BlaM 5 Other SeqMotif ABC Signature Other SeqMotif Walker B Mol Gen Genet 1992 Mar;232(1):40-8 J Mol Biol 1991 Feb 5;217(3):441-54 Reference for SeqMotif J Mol Biol. 2003 Jul 4;330(2):333-42. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. EMBO J. 2005 Jun 1;24(11):1901-10. Epub 2005 May 12. EMBO J. 2006 Jul 26;25(14):3432-43. Epub 2006 Jul 6. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Mitochondrial import inner membrane translocase subunit TIM17 Saccharomyces cerevisiae P39515 Q02310 D6VW42 MSADHSRDPC PIVILNDFGG AFAMGAIGGV VWHGIKGFRN SPLGERGSGA MSAIKARAPV LGGNFGVWGG LFSTFDCAVK AVRKREDPWN AIIAGFFTGG ALAVRGGWRH TRNSSITCAC LLGVIEGVGL MFQRYAAWQA KPMAPPLPEA PSSQPLQA Mitochondrial inner membrane;Matrix;Inter membrane space 69 Immunolocalisation Epitope Insertion (ETcm epitope) FEBS Lett 1994 Aug 1;349(2):222-8 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Colicin A immunity protein Citrobacter freundii P05701 MMNEHSIDTD NRKANNALYL FIIIGLIPLL CIFVVYYKTP DALLLRKIAT STENLPSITS SYNPLMTKVM DIYCKTAPFL ALILYILTFK IRKLINNTDR NTVLRSCLLS PLVYAAIVYL FCFRNFELTT AGRPVRLMAT NDATLLLFYI GLYSIIFFTT YITLFTPVTA FKLLKKRQ Bacterial inner membrane;Cytoplasm;Periplasmic space 88 Immunolocalisation Epitope Insertion (ColA epitope) Fusion PhoA 158 2999794 Fusion PhoA 0.75 2999794 Fusion PhoA 109 2999794 Proc Natl Acad Sci U S A 1988 Feb;85(3):689-93 No numerical data Mol Microbiol 1989 May;3(5):679-87 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Inositol 1,4,5-trisphosphate-binding protein type 1 receptor, Type 1 INSP3 receptor Rattus norvegicus P29994 Q62869 3.77 XRAY 3.60 XRAY 3.00 XRAY MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK EGQKEDRDVL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGASKDEIK ERFAQTMEFV EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN LFLNPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LFMYHIHLVE LLAVCTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYINFLNHC YVDTEVEMKE IYTSNHMWKL FENFLVDICR ACNNTSDRKH ADSVLEKYVT EIVMSIVTTF FSSPFSDQST TLQTRQPVFV QLLQGVFRVY HCNWLMPSQK ASVESCIRVL SDVAKSRAIA IPVDLDSQVN NLFLKSHNIV QKTAMNWRLS ARNAARRDSV LAASRDYRNI IERLQDIVSA LEDRLRPLVQ AELSVLVDVL HRPELLFPEN TDARRKCESG GFICKLIKHT KQLLEENEEK LCIKVLQTLR EMMTKDRGYG EKQISIDELE NAELPQPPEA ENSTEELEPS PPLRQLEDHK RGEALRQILV NRYYGNIRPS GRRESLTSFG NGPLSPGGPS KPGGGGGGPG SGSTSRGEMS LAEVQCHLDK EGASNLVIDL IMNASSDRVF HESILLAIAL LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY DRMKVAQQEI KATVTVNTSD LGNKKKDDEV DRDAPSRKKA KEPTTQITEE VRDQLLEASA ATRKAFTTFR READPDDHYQ SGEGTQATTD KAKDDLEMSA VITIMQPILR FLQLLCENHN RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LINQTLESLT EYCQGPCHEN QNCIATHESN GIDIITALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME SRHDSENAER ILYNMRPKEL VEVIKKAYMQ GEVEFEDGEN GEDGAASPRN VGHNIYILAH QLARHNKELQ TMLKPGGQVD GDEALEFYAK HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG LLWTAMLISL AIVIALPKPH GIRALIASTI LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS FVGNCGTFTR GYRAMVLDVE FLYHLLYLLI CAMGLFVHEF FYSLLLFDLV YREETLLNVI KSVTRNGRPI ILTAALALIL VYLFSIVGYL FFKDDFILEV DRLPNETAGP ETGESLANDF LYSDVCRVET GENCTSPAPK EELLPVEETE QDKEHTCETL LMCIVTVLSH GLRSGGGVGD VLRKPSKEEP LFAARVIYDL LFFFMVIIIV LNLIFGVIID TFADLRSEKQ KKEEILKTTC FICGLERDKF DNKTVTFEEH IKEEHNMWHY LCFIVLVKVK DSTEYTGPES YVAEMIRERN LDWFPRMRAM SLVSSDSEGE QNELRNLQEK LESTMKLVTN LSGQLSELKD QMTEQRKQKQ RIGLLGHPPH MNVNPQQPA Endoplasmic reticulum membrane;Cytoplasm;Cysternal space 73 Structure PDB Structure PDB Structure PDB Structure PDB Other Tailoring DTM The protein fragment containing residues 1-2110 was soluble, i.e. does not contain transmembrane segment. Structure PDB Structure PDB Immunolocalisation Structure PDB Structure PDB PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination PostTransMod Ubiquitination Immunolocalisation Epitope Insertion (PP epitope) PostTransMod Ubiquitination Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation Immunolocalisation Epitope Insertion (PP epitope) Immunolocalisation J Biol Chem 1999 Oct 8;274(41):29483-92 The sequence length are 2734 in this article, using type-1 S1b isoform (probable missing residues 322-336), therefore 15 was added for each sequence number larger than 336. No numerical data J Biol Chem. 2008 Dec 19;283(51):35319-28. doi: 10.1074/jbc.M807288200. Epub 2008 Nat Struct Mol Biol. 2011 Sep 4;18(10):1172-4. doi: 10.1038/nsmb.2112. Nature. 2012 Jan 29;483(7387):108-12. doi: 10.1038/nature10751. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Diacylglycerol kinase, DAGK, DGK Escherichia coli P0ABN1 P00556 Q2M6R2 N/A NMR According to 19556511/Fig2 2.05 XRAY According to 23676677/Fig1 3.70 XRAY According to 23676677/Fig1 3.10 XRAY According to 23676677/Fig1 3.30 XRAY by similarity 2.55 XRAY by similarity 2.44 XRAY by similarity 2.28 XRAY According to 25012698/Fig8 MANNTTGFTR IIKAAGYSWK GLRAAWINEA AFRQEGVAVL LAVVIACWLD VDAITRVLLI SSVMLVMIVE ILNSAIEAVV DRIGSEYHEL SGRAKDMGSA AVLIAIIVAV ITWCILLWSH FG Bacterial inner membrane;Cytoplasm;Periplasmic space 94 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 0 Fusion LacZ + Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 0 Fusion LacZ + Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion LacZ - Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 450 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion LacZ - Structure PDBTM Structure PDBTM Fusion LacZ + Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion LacZ + Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion BlaM 450 Fusion LacZ - Structure PDBTM Fusion PhoA 1.72 Fusion GFP 0.01 J Bacteriol 1994 Sep;176(17):5459-65 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Science. 2009 Jun 26;324(5935):1726-9. doi: 10.1126/science.1171716. Nature. 2013 May 23;497(7450):521-4. doi: 10.1038/nature12179. Epub 2013 May 15. To be published Cell Mol Life Sci. 2014 Jul 11. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Sensor protein kdpD Escherichia coli P21865 N/A NMR by similarity MNNEPLRPDP DRLLEQTAAP HRGKLKVFFG ACAGVGKTWA MLAEAQRLRA QGLDIVVGVV ETHGRKDTAA MLEGLAVLPL KRQAYRGRHI SEFDLDAALA RRPALILMDE LAHSNAPGSR HPKRWQDIEE LLEAGIDVFT TVNVQHLESL NDVVSGVTGI QVRETVPDPF FDAADDVVLV DLPPDDLRQR LKEGKVYIAG QAERAIEHFF RKGNLIALRE LALRRTADRV DEQMRAWRGH PGEEKVWHTR DAILLCIGHN TGSEKLVRAA ARLASRLGSV WHAVYVETPA LHRLPEKKRR AILSALRLAQ ELGAETATLS DPAEEKAVVR YAREHNLGKI ILGRPASRRW WRRETFADRL ARIAPDLDQV LVALDEPPAR TINNAPDNRS FKDKWRVQIQ GCVVAAALCA VITLIAMQWL MAFDAANLVM LYLLGVVVVA LFYGRWPSVV ATVINVVSFD LFFIAPRGTL AVSDVQYLLT FAVMLTVGLV IGNLTAGVRY QARVARYREQ RTRHLYEMSK ALAVGRSPQD IAATSEQFIA STFHARSQVL LPDDNGKLQP LTHPQGMTPW DDAIAQWSFD KGLPAGAGTD TLPGVPYQIL PLKSGEKTYG LVVVEPGNLR QLMIPEQQRL LETFTLLVAN ALERLTLTAS EEQARMASER EQIRNALLAA LSHDLRTPLT VLFGQAEILT LDLASEGSPH ARQASEIRQH VLNTTRLVNN LLDMARIQSG GFNLKKEWLT LEEVVGSALQ MLEPGLSSPI NLSLPEPLTL IHVDGPLFER VLINLLENAV KYAGAQAEIG IDAHVEGENL QLDVWDNGPG LPPGQEQTIF DKFARGNKES AVPGVGLGLA ICRAIVDVHG GTITAFNRPE GGACFRVTLP QQTAPELEEF HEDM Bacterial inner membrane;Cytoplasm;Periplasmic space 96 Fusion PhoA 10 1100846 Fusion LacZ 225 M1971 Structure PDBTM Fusion PhoA 8 1100846 Fusion LacZ 392 M1971 Structure PDBTM Structure PDBTM Fusion PhoA 505 1100846 Fusion LacZ 3 M1971 Fusion PhoA 11 1100846 Structure PDBTM Structure PDBTM Fusion LacZ 209 M1971 Fusion PhoA 22 1100846 Structure PDBTM Structure PDBTM Fusion LacZ 50 M1971 Structure PDBTM Structure PDBTM Fusion PhoA 0.00 Fusion GFP 0.54 J Biol Chem 1995 Nov 24;270(47):28282-8 Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Colibri gene id: KdpD Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10902-7. doi: Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Alpha-ketoglutarate permease Escherichia coli P17448 P0AEX3 P0AEX4 MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH IFFPSGNTTT QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV CMMCFGSLVI ACLPGYETIG TWAPALLLLA RLFQGLSVGG EYGTSATYMS EVAVEGRKGF YASFQYVTLI GGQLLALLVV VVLQHTMEDA ALREWGWRIP FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR NRRAFIMVLG FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV SFYTSISGIL KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG METAFFWYVT LMAVVAFLVS LMLHRKGKGM RL Bacterial inner membrane;Cytoplasm;Periplasmic space 85 Fusion PhoA 13 1645718 9 Fusion PhoA 5 1645718 1 Fusion PhoA 13 1645718 11 Fusion PhoA 591 1645718 181 Fusion PhoA 268 1645718 106 Fusion PhoA 996 1645718 97 Fusion PhoA 6 1645718 4 Fusion PhoA 216 1645718 106 Fusion PhoA 353 1645718 155 Fusion PhoA 264 1645718 94 Fusion PhoA 20 1645718 17 Fusion PhoA 33 1645718 19 Fusion PhoA 4 1645718 2 Fusion PhoA 426 1645718 92 Fusion PhoA 621 1645718 161 Fusion PhoA 111 1645718 29 Fusion PhoA 69 1645718 7 Fusion PhoA 458 1645718 122 Fusion PhoA 468 1645718 74 Fusion PhoA 66 1645718 7 Fusion PhoA 245 1645718 53 Fusion PhoA 0.00 J Bacteriol 1993 Jan;175(2):565-7 Science. 2005 May 27;308(5726):1321-3. Colibri gene id: KgtP Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Polysialic acid transport protein kpsM Escherichia coli P23889 MARSGFEVQK VTVEALFLRE IRTRFGKFRL GYLWAILEPS AHLLILLGIL GYVMHRTMPD ISFPVFLLNG LIPFFIFSSI SKRSIGAIEA NQGLFNYRPV KPIDTIIARA LLETLIYVAV YILLMLIVWM TGEYFEITNF LQLVLTWSLL IILSCGVGLI FMVVGKTFPE MQKVLPILLK PLYFISCIMF PLHSIPKQYW SYLLWNPLVH VVELSREAVM PGYISEGVSL NYLAMFTLVT LFIGLALYRT REEAMLTS Bacterial inner membrane;Cytoplasm;Periplasmic space 84 Fusion PhoAS 0 6339478 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM 50 Fusion BlaM 100 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 50 Fusion PhoAS 129 6339478 Fusion BlaM 100 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM less than 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 5 Fusion BlaM 100 Fusion PhoAS 116 6339478 Fusion PhoAS 60 6339478 Fusion BlaM 5 Fusion BlaM 100 Fusion BlaM 100 Fusion BlaM 100 Fusion BlaM 100 Fusion BlaM 5 Mol Microbiol 1994 Dec;14(5):871-81 Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Lactose permease Escherichia coli P02920 Q2MC81 N/A MODEL fig 2 3.50 XRAY fig 1 3.60 XRAY fig 1 3.3 XRAY fig 1 2.95 XRAY fig 1 3.60 XRAY According to 17881559/Fig1 3.38 XRAY 12471022 ("LacY is a 12-transmembrane-helix bundle with the N and C termini on the cytoplasmic face of the membrane ") MYYLKNTNFW MFGLFFFFYF FIMGAYFPFF PIWLHDINHI SKSDTGIIFA AISLFSLLFQ PLFGLLSDKL GLRKYLLWII TGMLVMFAPF FIFIFGPLLQ YNILVGSIVG GIYLGFCFNA GAPAVEAFIE KVSRRSNFEF GRARMFGCVG WALCASIVGI MFTINNQFVF WLGSGCALIL AVLLFFAKTD APSSATVANA VGANHSAFSL KLALELFRQP KLWFLSLYVI GVSCTYDVFD QQFANFFTSF FATGEQGTRV FGYVTTMGEL LNASIMFFAP LIINRIGGKN ALLLAGTIMS VRIIGSSFAT SALEVVILKT LHMFEVPFLL VGCFKYITSQ FEVRFSATIY LVCFCFFKQL AMIFMSVLAG NMYESIGFQG AYLVLGLVAL GFTLISVFTL SGPGPLSLLR RQVNEVA Bacterial inner membrane;Cytoplasm;Periplasmic space 90 Immunolocalisation Epitope Insertion Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 635 6339478 Fusion PhoALacZ 640 1943817 Fusion PhoALacZ 177 M1971 Fusion PhoALacZ 1485 1943817 Fusion PhoALacZ 37 M1971 Fusion PhoALacZ 2368 1943817 Fusion PhoALacZ 81 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 376 6339478 Other Tailoring TCSI Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Other Tailoring TCSI Fusion PhoA 15 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 4 6339478 Structure PDBTM Structure PDBTM Fusion PhoA 3 6339478 Structure PDBTM Structure PDBTM Fusion PhoA less than 1 6339478 Fusion PhoA 11 6339478 Fusion PhoALacZ 1597 1943817 Fusion PhoALacZ 42 M1971 Fusion PhoA 621 6339478 Fusion PhoA 722 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 436 1943817 Fusion PhoALacZ 62 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 380 1943817 Fusion PhoALacZ 2200 1943817 Fusion PhoALacZ 10 M1971 Fusion PhoALacZ 130 1943817 Fusion PhoALacZ 5 M1971 Fusion PhoALacZ 794 1943817 Fusion PhoALacZ 67 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 456 6339478 Structure PDBTM Fusion PhoA 372 6339478 Structure PDBTM Structure PDBTM Fusion PhoA 65 6339478 Immunolocalisation Epitope Insertion (ISO epitope) Fusion PhoA 99 6339478 Structure PDBTM Structure PDBTM Fusion PhoALacZ 37 1943817 Fusion PhoALacZ 179 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion (ISO epitope) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 4 6339478 Fusion PhoA 5 6339478 Fusion PhoA 4 6339478 Fusion PhoA 191 6339478 Fusion PhoALacZ 1114 1943817 Fusion PhoALacZ 66 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 1822 1943817 Fusion PhoALacZ 30 M1971 Fusion PhoA 400 6339478 Fusion PhoALacZ 1751 1943817 Fusion PhoALacZ 15 M1971 Structure PDBTM Immunolocalisation Epitope Insertion (ISO epitope) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 164 1943817 Fusion PhoALacZ 456 M1971 Fusion PhoA 30 1943817 Fusion PhoALacZ 25 1943817 Fusion PhoALacZ 140 M1971 Fusion PhoALacZ 30 1943817 Fusion PhoALacZ 130 M1971 Fusion PhoALacZ 10 1943817 Fusion PhoALacZ 40 M1971 Fusion PhoA 13 6339478 Fusion PhoALacZ 249 1943817 Fusion PhoALacZ 662 M1971 Fusion PhoALacZ 131 1943817 Fusion PhoALacZ 356 M1971 Structure PDBTM Fusion PhoA 12 6339478 Structure PDBTM Structure PDBTM Fusion PhoA 12 6339478 Fusion PhoA 5 6339478 Structure PDBTM Fusion PhoA 5 6339478 Fusion PhoA 10 6339478 Structure PDBTM Fusion PhoA 5 6339478 Structure PDBTM Fusion PhoA 5 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 5 6339478 Structure PDBTM Structure PDBTM Fusion PhoA 5 6339478 Fusion PhoA 20 6339478 Fusion PhoA 300 6339478 Fusion PhoA 500 6339478 Fusion PhoA 330 6339478 Fusion PhoALacZ 2547 1943817 Fusion PhoALacZ 6 M1971 Structure PDBTM Fusion PhoA 480 6339478 Fusion PhoA 420 6339478 Fusion PhoA 400 6339478 Fusion PhoA 370 6339478 Fusion PhoA 482 6339478 Chemical_modification Quenching Fusion PhoA 430 6339478 Fusion PhoA 380 6339478 Fusion PhoALacZ 2775 1943817 Fusion PhoALacZ 5 M1971 Fusion PhoA 390 6339478 Fusion PhoA 507 6339478 Fusion PhoALacZ 3547 1943817 Fusion PhoALacZ 5 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 400 6339478 Immunolocalisation Epitope Insertion (RSO epitope) Fusion PhoALacZ 2625 1943817 Fusion PhoALacZ 4 M1971 Other Tailoring TCSI Structure PDBTM Fusion PhoALacZ 1465 1943817 Fusion PhoALacZ 10 M1971 Fusion PhoA 290 6339478 Fusion PhoA 280 6339478 Fusion PhoA 272 6339478 Fusion PhoA 320 1943817 Fusion PhoALacZ 520 1943817 Fusion PhoALacZ 5 M1971 Fusion PhoALacZ 540 1943817 Fusion PhoALacZ 5 M1971 Fusion PhoALacZ 240 1943817 Fusion PhoALacZ 3 M1971 Fusion PhoALacZ 2848 1943817 Fusion PhoALacZ 7 M1971 Fusion PhoA 399 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 2550 1943817 Fusion PhoALacZ 6 M1971 Structure PDBTM Fusion PhoALacZ 1929 1943817 Fusion PhoALacZ 13 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion (RSO epitope) Structure PDBTM Structure PDBTM Fusion PhoA 3 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 526 1943817 Fusion PhoALacZ 65 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 90 6339478 Fusion PhoALacZ 280 1943817 Fusion PhoALacZ 131 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion (RSO epitope) Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion (RSO epitope) Structure PDBTM Structure PDBTM Immunolocalisation Epitope Insertion (RSO epitope) Fusion PhoA 4 6339478 Immunolocalisation Epitope Insertion (RSO epitope) Fusion PhoALacZ 0 1943817 Fusion PhoALacZ 405 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 20 6339478 Structure PDBTM Fusion PhoA 35 6339478 Fusion PhoA 85 6339478 Fusion PhoA 80 6339478 Fusion PhoA 80 6339478 Chemical_modification Quenching Fusion PhoALacZ 2026 1943817 Fusion PhoALacZ 10 M1971 Fusion PhoALacZ 394 1943817 Fusion PhoALacZ 60 M1971 Fusion PhoA 242 6339478 Fusion PhoA 46 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 247 6339478 Fusion PhoA 85 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Other Tailoring TCSI Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 244 6339478 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoALacZ 33 1943817 Fusion PhoALacZ 140 M1971 Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 32 6339478 Fusion PhoA 10 1943817 Fusion PhoALacZ 2 1943817 Fusion PhoALacZ 240 M1971 Fusion PhoALacZ 2 1943817 Fusion PhoALacZ 70 M1971 Immunolocalisation Epitope Insertion (ISO epitope) Immunolocalisation Epitope Insertion (ISO epitope) Immunolocalisation Epitope Insertion (ISO epitope) Fusion PhoALacZ 48 1943817 Fusion PhoALacZ 948 M1971 Fusion PhoA 23 6339478 Fusion PhoA 0.00 Fusion GFP 1.75 Immunolocalisation Epitope Insertion Proc Natl Acad Sci U S A 1990 Jul;87(13):4937-41 No numerical data Biochemistry 1986 May 6;25(9):2403-9 Biochemistry 1985 Jan 1;24(1):221-9 No numerical data J Biol Chem 1983 Sep 25;258(18):10817-20 No numerical data Proc Natl Acad Sci U S A 1984 Aug;81(15):4672-6 No numerical data Biochemistry 1984 Jul 31;23(16):3681-7 No numerical topology data given No numerical data Proc Natl Acad Sci U S A 1982 Nov;79(22):6894-8 No numerical topology data given No numerical data Biochemistry 1995 Nov 14;34(45):14909-17 Biochemistry 1996 Jan 23;35(3):990-8 No numerical data Biochemistry 1997 Jan 7;36(1):274-80 J Mol Biol 1997 Mar 28;267(2):250-63 No numerical topology data given No numerical data Protein Eng 1997 Jun;10(6):715-23 No numerical data J Mol Biol 1999 Jan 29;285(4):1503-13 No numerical data J Bacteriol 1999 Oct;181(19):6108-13 No numerical data Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14037-40. Epub 2002 Oct 21. J Biol Chem. 2003 Mar 21;278(12):10641-8. Epub 2002 Dec 5. Science. 2003 Aug 1;301(5633):610-5. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Colibri gene id: LacY EMBO J. 2006 Mar 22;25(6):1177-83. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15294-8. Epub 2007 Sep 19. Copyrighted by the Institute of Enzymology, see http://topdb.enzim.hu/?m=terms. Distributed under the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) License Signal peptidase I Escherichia coli P00803 P78098 Q2MAG2 1.95 XRAY >>The signal peptidase (SPase) from Escherichia coli is a membrane-bound endopeptidase with two amino-terminal transmembrane segments and a carboxy-terminal catalytic region which resides in the periplasmic space<< (9823901) 2.40 XRAY >>E. coli SPase (323 amino acids, 35,988 Da, pI 6.9) contains two amino-terminal transmembrane segments (residues 4-28 and 58-76), a small cytoplasmic region (residues 29-58), and a carboxyl-terminal periplasmic catalytic region (residues 77-323).<< (11741964) 2.47 XRAY >>E. coli SPase (323 amino acids, 35,988 Da, pI 6.9) contains two amino-terminal transmembrane segments (residues 4–28 and 58–76), a small cytoplasmic region (residues 29–58), and a carboxyl-terminal periplasmic catalytic region (residues 77–323).<< (15136583) MANMFALILV IATLVTGILW CVDKFFFAPK RRERQAAAQA AAGDSLDKAT LKKVAPKPGW LETGASVFPV LAIVLIVRSF IYEPFQIPSG SMMPTLLIGD FILVEKFAYG IKDPIYQKTL IETGHPKRGD IVVFKYPEDP KLDYIKRAVG LPGDKVTYDP VSKELTIQPG CSSGQACENA LPVTYSNVEP SDFVQTFSRR NGGEATSGFF EVPKNETKEN GIRLSERKET LGDVTHRILT VPIAQDQVGM YYQQPGQQLA TWIVPPGQYF MMGDNRDNSA DSRYWGFVPE ANLVGRATAI WMSFDKQEGE WPTGLRLSRI GGIH Bacterial inner membrane;Cytoplasm;Periplasmic space 96 Fusion PhoA 168 Unknown Fusion PhoA 15 Unknown Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 1200 Unknown Structure PDBTM Fusion PhoA N/A Unknown yes Fusion PhoA 882 Unknown yes Structure PDBTM Structure PDBTM Fusion PhoA N/A Unknown yes Structure PDBTM Fusion PhoA 850 Unknown yes Fusion PhoA N/A Unknown yes Fusion PhoA N/A Unknown yes Fusion PhoA 1011 Unknown yes Structure PDBTM Structure PDBTM Structure PDBTM Fusion PhoA 4.53 Fusion GFP 0.04 J Bacteriol 1989 Oct;171(10):5536-41 Nature. 1998 Nov 12;396(6707):186-90. J Biol Chem. 2002 Mar 15;277(11):9512-9. Epub 2001 Dec 10. J Biol Chem. 2004 Jul 16;279(29):30781-90. Epub 2004 May 10. Bioinformatics. 2004 Nov 22;20(17):2964-72. Epub 2004 Jun 4. Science. 2005 May 27;308(5726):1321-3. Colibri gene id: LepB