TOPDB Topology Data Bank of Transmembrane Proteins
Topology, Structure and Prediction.
Database revision: 4 (3436 entries, 65238 topology data) Quick search:    

Database status

Database revision: 4
Revision date: 06/25/14
Entries: 3436
Topology data: 65238
Alpha helical proteins: 3323
Beta barrel proteins: 113
PubMed links: 2977
PDB links: 8326
UniProt links: 3418
Visitors: 32971

TOPDB: Topology Database of Transmembrane Proteins


The Topology Data Bank of Transmembrane Proteins (TOPDB) is currently the most complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information. It contains records for 3436 transmembrane proteins with information gathered from the literature and from public databases available on the World Wide Web.

The database collects the details of various experiments carried out to learn about the topology of particular transmembrane proteins. The experimental techniques include fusion with reporter enzymes, glycolysation studies, protease accessibility, immunolocalisation, etc. In addition to literature-derived data, an extensive collection of structural data was also compiled from Protein Data Bank (PDB) and from Protein Data Bank of Transmembrane Proteins (PDBTM) by utilising the TMDET algorithm.

While literature-derived data can not be collected automatically, data based on 3D structures provides semi-automatic and continuously updated information for the database. Structural data is the most reliable information about transmembrane topologies, but the topology information is often incomplete. Therefore, for each protein in the database the most probable topology consistent with the collected experimental constraints was also calculated using HMMTOP transmembrane topology prediction algorithm.

Each record in TOPDB also contains the indispensable information about the given protein such as its sequence, name, organism and cross references to various databases (PDB, PDBTM, UniProt and literature references from PubMed).

This web interface of TOPDB includes tools for extensive searching, relational querying and data browsing as well as visualisation tools for topology data.

The TOPDB is designed to address the broad gap between the large number of transmembrane proteins in sequence databases and the publicly available topology information of experimentally or computationally studied transmembrane proteins.


Tusnády GE, Kalmár L and Simon I (2008)
TOPDB: Topology Data Bank of Transmembrane Proteins.
Nucleic Acids Research Database issue, in press.
[Journal] [Medline] [PDF] [HTML]

Related manuscripts

Gardy JL, Spencer C, Wang K, Ester M, Tusnády GE, Simon I, Hua S, deFays K, Lambert C, Nakai K and Brinkman FS (2003)
PSORT-B: improving protein subcellular localization prediction for Gram-negative bacteria.
Nucleic Acids Res 31, 3613-3617.
[Journal] [Medline] [PDF] [Server]
Dosztányi Zs, Magyar Cs, Tusnády GE, Cserző M, Fiser A and Simon I (2003)
Servers for sequence-structure relationship analysis and prediction.
Nucleic Acids Res 31, 3359-3363.
[Journal] [Medline] [PDF] [Servers]
Tusnády GE, Dosztányi Zs and Simon I (2004)
Transmembrane proteins in protein data bank: identification and classification.
Bioinformatics 20, 2964-2972.
[Journal] [Medline] [PDF] [Server]
Tusnády GE, Dosztányi Zs and Simon I (2004)
TMDET: web server for detecting transmembrane domains by using 3D structure of proteins
Bioinformatics , (in press).
[Journal] [Medline] [PDF] [Server]
Tusnády GE, Dosztányi Zs and Simon I (2005)
PDB_TM: selection and membrane localization of transmembrane proteins in the Protein Data Bank.
Nucleic Acids Research 33 Database Issue, D275-D278.
[Journal] [Medline] [PDF] [Server]

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